Who is sponsoring NCT05580666?

NCT05580666 is sponsored by Population Health Research Institute.

What drugs are being tested in NCT05580666?

Interventions in NCT05580666: Azithromycin Oral Tablet, Placebo oral tablet.

What condition does NCT05580666 study?

NCT05580666 studies HIV Disease Progression.

Is NCT05580666 still recruiting?

NCT05580666 is currently recruiting now. Last updated 3 September 2025.

Last reviewed 2025-09-03 · How we verify

NCT05580666: REVIVE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)

Recruiting now Phase 3 Last updated 3 September 2025

What this trial tests

Phase 3 trial testing Azithromycin Oral Tablet in HIV Disease Progression in 8,000 participants. Currently enrolling.

Timeline

8 May 2023

Primary endpoint
30 November 2028

31 May 2029

Quick facts

Lead sponsor	Population Health Research Institute
Phase	Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	8,000
Start date	8 May 2023
Primary completion	30 November 2028
Estimated completion	31 May 2029
Sites	52 locations across Ethiopia, South Africa, Ghana, Malawi, Zambia, Nigeria, Rwanda, Mozambique

Drugs / interventions tested

Azithromycin Oral Tablet
Placebo oral tablet — full drug profile →

Conditions studied

HIV Disease Progression — all drugs for HIV Disease Progression →

Sponsor

Population Health Research Institute

Who can join

18 and older, any sex, with HIV Disease Progression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced HIV.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Standard of care in advanced HIV disease: review of HIV treatment guidelines in six sub-Saharan African countries.
Scheier TC, Youssouf N, Mosepele M, Kanyama C, et al · · 2023 · cited 7× · PMID 37996881 · DOI 10.1186/s12981-023-00581-5
Standard of care in advanced HIV disease: review of HIV treatment guidelines in sub-Saharan African countries-an extension study of eight countries.
Scheier TC, Tufa TB, Feldt T, Hardy Y, et al · · 2025 · cited 3× · PMID 40158188 · DOI 10.1186/s12981-025-00733-9
mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease.
Wake RM, Govender NP. · · 2025 · PMID 40214248 · DOI 10.1128/mbio.00769-24

Verify or expand the search:

Other trials of Azithromycin Oral Tablet

Trials testing the same drug.

NCT05764876 — Repurposing Clinically Approved Drugs for Yaws with an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws) · Phase 3 · completed
NCT05157685 — Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults · Phase 3 · recruiting

Other Population Health Research Institute trials

Trials by the same sponsor.

NCT07511543 — Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy · Phase 2 · not yet recruiting
NCT07468448 — Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe · Phase 3 · not yet recruiting
NCT06587737 — Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage · Phase 3 · not yet recruiting
NCT07011095 — DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial · EARLY_PHASE1 · not yet recruiting
NCT06508164 — International CRDS Registry · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05580666 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Population Health Research Institute
Last refreshed: 3 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05580666.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing