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NCT05579392
A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis
NA trial testing Bright Light Therapy in Inflammatory Bowel Disease in 30 participants. Currently enrolling.
1 May 2026
Quick facts
| Lead sponsor | Rush University Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 22 September 2022 |
| Primary completion | 1 May 2026 |
| Estimated completion | 31 May 2026 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Bright Light Therapy
- Placebo Retimer Device
Conditions studied
- Inflammatory Bowel Disease — all drugs for Inflammatory Bowel Disease →
Sponsor
Rush University Medical Center
Who can join
18 and older, any sex, with Inflammatory Bowel Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are two of the most significant chronic conditions of the gastrointestinal tract (GIT) and affects over 1.5 million individuals in the U.S. Recently, there has been an increased understanding of the importance of sleep and sleep disruption in IBD as a potentially modifiable risk factor. We, therefore, hypothesize that intervening with morning bright light therapy (BLT) in IBD patients with CM will decrease intestinal permeability and pro-inflammatory cytokines, positively impact intestinal microbiota, and improve quality of life (QoL).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05579392
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Bright Light Therapy
Trials testing the same drug.
- NCT07424703 — Effect of Bright Light Therapy on Idiopathic Scoliosis · NA · recruiting
- NCT06092411 — Effects of CBT and BLT in Youth With Unipolar Depression and Evening Chronotype · NA · recruiting
- NCT06329479 — A Feasibility Trial for Circadian Rest-activity Rhythm Disorders in Cancer (RALI) · NA · completed
- NCT05337943 — Cognitive Behavioral Therapy and Light Therapy · NA · completed
- NCT04845347 — A Wearable Morning Light Treatment for Postpartum Depression · NA · completed
Other recruiting trials for Inflammatory Bowel Disease
Currently open trials in the same condition.
- NCT07210580 — Testing the Impact of Measurement-Based Care on Quality of Life and Disease Management Among Veterans With Inflammatory · NA · recruiting
- NCT07242248 — A Study to Observe Real-world Evidence of Guselkumab Treatment in Participants With Ulcerative Colitis and Crohn's Disea · recruiting
- NCT07102368 — A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in Germany · recruiting
- NCT07252427 — Gut Microbiota in IBD With Comorbid Depressive Disorder · recruiting
- NCT06781827 — Research on the Use of Probiotics in the Prevention and Treatment of Inflammatory Bowel Disease · NA · recruiting
Other Rush University Medical Center trials
Trials by the same sponsor.
- NCT07278076 — Clinical Decision-Making During FEES: The Impact of Residue Amount and Location · NA · not yet recruiting
- NCT07088120 — PRECISION-CPR: PRecision-Controlled Ventilation in CPR · NA · not yet recruiting
- NCT06894719 — Oral Tranexamic Acid After Total Knee Arthroplasty · Phase 4 · not yet recruiting
- NCT06229392 — A Study to Evaluate the Intratumoral Influenza Vaccine Administration in Patients With Breast Cancer · Phase 1 · withdrawn
- NCT07452406 — Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05579392 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rush University Medical Center
- Last refreshed: 12 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05579392.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing