CO2 Gap Changes in Septic Shock in Relation to Cardiac Output

NCT05578534 COMPLETED

Background The arteriovenous difference of partial pressure of carbon dioxide (PCO2) between mixed or central venous blood and arterial blood is the ∆PCO2 or CO2 gap. Previous data demonstrated a strong relationship between ∆PCO2 and cardiac index (CI) at the very early phase of resuscitation in septic shock. Monitoring the ∆PCO2 from the beginning of the resuscitation may be a useful tool to assess the adequacy of cardiac output (CO) in tissue perfusion. Aim of work: To examine behavior of ∆PCO2 during early management of septic shock. Methodology: Seventy-six patients with diagnosis of septic shock admitted to critical care department, Cairo university hospitals. We classified the study population according to initial resuscitation response, initial CO2 gap, or 28-days mortality. The response vs non-response to initial resuscitation, ICU morbidity and recovery rate were the study primary outcomes while secondary outcomes included ICU length of stay (LOS) and 28-day ICU Mortality.

Details

Lead sponsor	Cairo University
Status	COMPLETED
Enrolment	76
Start date	Tue Dec 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sat Oct 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Septic Shock

Countries

Egypt