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NCT05577429
The Potential of a Low Oxygen Environmental Chamber as an Aid to Exercise Training to Improve Metabolic Health
NA trial testing Low-moderate intensity exercise under normoxia in Overweight in 14 participants. Completed in 17 March 2022.
17 March 2022
Quick facts
| Lead sponsor | Swinburne University of Technology |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 14 |
| Start date | 3 June 2021 |
| Primary completion | 17 March 2022 |
| Estimated completion | 17 March 2022 |
| Sites | 1 location across Malaysia |
Drugs / interventions tested
- Low-moderate intensity exercise under normoxia
- Low-moderate intensity exercise under moderate hypoxia
- Low-moderate intensity exercise under high hypoxia
Conditions studied
- Overweight — all drugs for Overweight →
- Physical Inactivity — all drugs for Physical Inactivity →
- Healthy — all drugs for Healthy →
Sponsor
Swinburne University of Technology
Who can join
Adults 20 to 40, male only, with Overweight or Physical Inactivity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obesity is a major global health issue and a primary risk factor for metabolic-related disorders. While physical inactivity is one of the main contributors to obesity, it is a modifiable risk factor with exercise training as an established, non-pharmacological treatment to prevent the onset of metabolic-related disorders, including obesity. Exposure to hypoxia via normobaric hypoxia (simulated altitude via reduced inspired oxygen fraction), termed hypoxic conditioning, in combination with exercise has been increasingly shown in the last decade to enhance blood glucose regulation and decrease body mass index, providing a feasible strategy to treat obesity. Nonetheless, findings from studies investigating the potential for a hypoxic environment to augment the exercise training response and subsequent metabolic health are equivocal. Notably, there is a paucity of information regarding the optimal combination of exercise variables and hypoxic load (i.e. level of hypoxia) to enable an individualized and safe practice of exercising in a hypoxic environment. In the present randomized, single-blind, cross-over study, the investigators will investigate the effects of single-bout of exercise under normoxia (FiO2, 20.9%), moderate (FiO2, 16.5%) and high normobaric hypoxic conditions (FiO2, 14.8%) (60-min cycling session at 90% LT) on 2h OGTT and 24h-glucose level in individuals with overweight. The investigators hypothesize that exercise in combination with hypoxia improves glucose homeostasis in individuals with overweight.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Combined effects of exercise and different levels of acute hypoxic severity: A randomized crossover study on glucose regulation in adults with overweight.
Tee CCL, Parr EB, Cooke MB, Chong MC, et al · · 2023 · cited 3× · PMID 37123278 · DOI 10.3389/fphys.2023.1174926
Verify or expand the search:
- PubMed search for NCT05577429
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Swinburne University of Technology trials
Trials by the same sponsor.
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- NCT04398472 — Evaluation of the Nextdoor KIND Challenge · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05577429 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Swinburne University of Technology
- Last refreshed: 13 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05577429.
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