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Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study
This retrospective cohort study aims to investigate the effects of recombinant human growth hormone (rh-GH) on the euploid status of preimplantation blastocysts in AMA patients. Infertile patients aged 38-46 years old were recruited for study if they fulfill the inclusion criteria and do not have the exclusion criteria. Treatment group: Women received growth hormone (GH) supplement during antagonist protocol for ovarian stimulation. Control group: Women received antagonist protocol for ovarian stimulation. The primary outcome is the euploidy rate of blastocysts per stimulation cycle and per testing cycle.
Details
| Lead sponsor | ShangHai Ji Ai Genetics & IVF Institute |
|---|---|
| Phase | PHASE3 |
| Status | COMPLETED |
| Enrolment | 692 |
| Start date | Fri Jan 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Sep 30 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Growth Hormone
- Advanced Maternal Age
- PGT-A
Interventions
- Growth hormone
- GnRH antagonist
Countries
China