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NCT05573217

The Utility of Cell-free DNA Methylation Markers for Hepatocellular Carcinoma

Status unknown Last updated 10 October 2022
What this trial tests

trial in Cell-free Methylation Markers in 180 participants. Status unknown.

Timeline
1 July 2021
Primary endpoint
30 June 2023
30 June 2023

Quick facts

Lead sponsorNational Taiwan University Hospital
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment180
Start date1 July 2021
Primary completion30 June 2023
Estimated completion30 June 2023
Sites1 location across Taiwan

Conditions studied

Sponsor

National Taiwan University Hospital

Who can join

20 and older, any sex, with Cell-free Methylation Markers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The subjects of this study were patients with liver cancer diagnosed by physicians according to AASLD clinical criteria or pathological biopsy. Those who plan to receive systemic drug treatment for liver cancer in National Taiwan University Hospital include Nexavar, Lenvatinib, Avastin, Tecentriq, Strivarga, Cabometyx, Cyramza, Nivolunab, Pembrolizumab, and Yervoy. Weak and uncooperative patients were excluded from blood tests, which were performed with full informed consent for relevant tumor markers (AFP ,PIVKA-II and methylation analysis). The data are then counted and compared.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. DNA methylation in cell plasticity and malignant transformation in liver diseases.
    Kim M, Delgado E, Ko S. · · 2023 · cited 15× · PMID 36535346 · DOI 10.1016/j.pharmthera.2022.108334

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Other National Taiwan University Hospital trials

Trials by the same sponsor.

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Data sources for this page

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