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NCT05572905: ETAPA
Effect of Acute Bout of Exercise on Levels of PAHSA
NA trial testing Exercise in Insulin Sensitivity in 60 participants. Completed in 12 December 2025.
12 December 2025
Quick facts
| Lead sponsor | Lenka Rossmeislova |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 60 |
| Start date | 1 May 2021 |
| Primary completion | 12 December 2025 |
| Estimated completion | 12 December 2025 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- Exercise
- Fasting control
Conditions studied
- Insulin Sensitivity — all drugs for Insulin Sensitivity →
Sponsor
Lenka Rossmeislova
Who can join
Adults 25 to 80, any sex, with Insulin Sensitivity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Exercise represents an important tool in the prevention and treatment of metabolic disorders associated with obesity and aging, such as type 2 diabetes and cardiovascular disease. Besides skeletal muscle and its myokinins, the metabolic effects of exercise also rely on the induction of favorable changes in adipose tissue function. For example, adipose tissue is a source of lipokinins from the family of palmitic acid esters of hydroxy fatty acids (PAHSA), which have anti-inflammatory and insulin-sensitizing properties. We have recently shown that 4 months of exercise training increases PAHSA levels in adipose tissue and circulation. However, the mechanisms involved in the induction of PAHSA levels in response to exercise are unknown. The aim of the Effect of Acute Bout of Exercise on Levels of PAHSA (ETAPA) project is therefore to investigate the regulation of PAHSA metabolism in response to both acute and chronic exercise. To achieve this goal, we will employ state-of-the-art analytical methods to measure PAHSA levels in both adipose tissue and circulation of subjects of various ages and adiposity status. The main output of the ETAPA project will be the proof of principle regarding the important role of PAHSA lipokinins in exercise-induced enhancement of insulin sensitivity and the identification of potential drug targets that could be used to further improve PAHSA metabolism for the treatment of metabolic disorders associated with aging or obesity.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Circulating and Adipose Tissue Profiles of Fatty Acid Esters of Hydroxy-Fatty Acids in Women: Impact of Adiposity, Age, and Acute Exercise
Rossmeislová L, Šebo V, Gojda J, Koc M, et al · · 2026 · DOI 10.64898/2026.05.13.26352871
Verify or expand the search:
- PubMed search for NCT05572905
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exercise
Trials testing the same drug.
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- NCT07589725 — Mulligan Mobilization in Lateral Elbow Tendinopathy · NA · not yet recruiting
- NCT07524400 — Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease · NA · recruiting
- NCT06627569 — Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans · NA · not yet recruiting
Other recruiting trials for Insulin Sensitivity
Currently open trials in the same condition.
- NCT07247734 — The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation · Phase 2 · recruiting
- NCT06939959 — Evaluating the Efficacy of Topical Insulin for the Restoration of Ocular Surface Interface in Dry Eye Disease. · Phase 4 · recruiting
- NCT06649981 — Aging Resilience Through Microbiota Optimization and Regulation · Phase 1 · active not recruiting
- NCT06487832 — Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness · NA · recruiting
- NCT06878781 — Postprandial Metabolome and Metabolic Flexibility · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05572905 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lenka Rossmeislova
- Last refreshed: 19 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05572905.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing