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NCT05566548
Role of Bilirubin Molecular Species in Hepatic Encephalopathy and Acute-on-chronic Liver Failure
trial testing Liquid Chromatography-Mass Spectrometry Method to identify bilirubin molecular species in Hepatic Encephalopathy in 50 participants. Status unknown.
31 July 2023
Quick facts
| Lead sponsor | Medica Sur Clinic & Foundation |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 1 August 2022 |
| Primary completion | 31 July 2023 |
| Estimated completion | 1 August 2023 |
| Sites | 1 location across Mexico |
Drugs / interventions tested
- Liquid Chromatography-Mass Spectrometry Method to identify bilirubin molecular species
Conditions studied
- Hepatic Encephalopathy — all drugs for Hepatic Encephalopathy →
- Acute-On-Chronic Liver Failure — all drugs for Acute-On-Chronic Liver Failure →
Sponsor
Medica Sur Clinic & Foundation
Who can join
Adults 20 to 70, any sex, with Hepatic Encephalopathy or Acute-On-Chronic Liver Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
It has been identified that impaired liver function, as occurs in patients with liver cirrhosis, prevents proper conjugation of glucuronic acid with bilirubin; as a result, unconjugated bilirubin accumulates in the blood, and conjugated bilirubin is markedly altered to form diglucuronides or monoglucuronides. However, in the development and progress of acute-on-chronic liver failure (ACLF) there is not enough information about these processes and the possible concentration levels that they can take. Also Hepatic encephalopathy (HE) is a reversible complication, but with a high mortality rate in patients with acute or chronic liver failure, as well as a consequence of the formation of portosystemic shunts.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Bilirubin Molecular Species Play an Important Role in the Pathophysiology of Acute-on-Chronic Liver Failure.
Castillo-Castañeda SM, Cordova-Gallardo J, Rivera-Espinosa L, Chavez-Pacheco JL, et al · · 2024 · cited 4× · PMID 39125751 · DOI 10.3390/ijms25158181
Verify or expand the search:
- PubMed search for NCT05566548
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Currently open trials in the same condition.
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Other Medica Sur Clinic & Foundation trials
Trials by the same sponsor.
- NCT03440164 — Superior Silybin Bioavailability in Healthy Volunteers · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05566548 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medica Sur Clinic & Foundation
- Last refreshed: 7 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05566548.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing