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NCT05565235
Comparing Efficacy of Different Drugs Combinations for Serratus Anterior Block for Thoracotomy
Phase 4 trial testing patients will receive intraoperative serratus block with bupivacaine in Post Operative Pain, Acute in 78 participants. Status unknown.
10 September 2023
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 78 |
| Start date | 9 December 2022 |
| Primary completion | 10 September 2023 |
| Estimated completion | 10 November 2023 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- patients will receive intraoperative serratus block with bupivacaine — full drug profile →
- serratus block with bupivacaine /magnesium — full drug profile →
- serratus block with bupivacaine with nalbuphine — full drug profile →
Conditions studied
- Post Operative Pain, Acute — all drugs for Post Operative Pain, Acute →
Sponsor
Cairo University
Who can join
Adults 16 to 65, any sex, with Post Operative Pain, Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
We aim to compare efficacy and efficiency of serratus anterior block with bupivacaine alone to bupivacaine/magnesium and bupivacaine /nalbuphine in postoperative analgesia for thoracotomy surgery. Objectives: To compare bupivacaine alone, bupivacaine/magnesium and bupivacaine /nalbuphine in serratus anterior plane block for intraoperative and postoperative analgesia for thoracotomy surgery. * The time for 1st rescue analgesia. * Calculation of the opioid requirements; (the total intra-operative post-operative morphine consumption in first 24h postoperative). * Assessment of pain score (VAS)- rest, VAS-movement, VAS-cough during post-operative 24hrs period. Hypothesis: We hypothesize that magnesium sulfate and nalbuphine can reduce acute postoperative pain and result in efficacious postoperative analgesia due to block of the lateral cutaneous branches of the intercostal nerves (T2 - T6) by diffusion across the inter-fascial planes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05565235 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 13 December 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05565235.
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