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NCT05562596: NORPHY
Normal Pressure Hydrocephalus Biomarkers Investigation
trial testing Measurement of oxysterol profile, including 20 molecules, in liquor before and after surgery in Normal Pressure Hydrocephalus in 30 participants. Status unknown.
1 April 2024
Quick facts
| Lead sponsor | University of Roma La Sapienza |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 30 October 2022 |
| Primary completion | 1 April 2024 |
| Estimated completion | 1 July 2024 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Measurement of oxysterol profile, including 20 molecules, in liquor before and after surgery
Conditions studied
- Normal Pressure Hydrocephalus — all drugs for Normal Pressure Hydrocephalus →
- Cognitive Impairment — all drugs for Cognitive Impairment →
Sponsor
University of Roma La Sapienza
Who can join
Adults 60 to 85, any sex, with Normal Pressure Hydrocephalus or Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Normal Pressure Hydrocephalus (NPH) is a clinical condition that induces cognitive deterioration that can be reverted, at least in part, by introducing ventricular-peritoneal diversion controlled by a miniaturized valve system. Mechanisms involved in such an improvement of cognitive function after liquor diversion are unknown. Oxysterols are a family of cholesterol-related compounds having diverse biological functions. Among others, they are involved in cholesterol homeostasis in the brain and are detectable in liquor, potentially impacting neurodegeneration. NPH is an ideal clinical model to study oxysterol distribution in liquor before and after ventricular-peritoneal diversion.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05562596
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Normal Pressure Hydrocephalus
Currently open trials in the same condition.
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- NCT05910944 — European Study of Prodromal iNPH · recruiting
Other University of Roma La Sapienza trials
Trials by the same sponsor.
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- NCT07520968 — ABX Versus CHX in NSPT: a RCT · NA · active not recruiting
- NCT07109596 — Integration of Clinical, Biological and Psycho-social Variables for a Gender-sensitive Frailty Prediction · recruiting
- NCT07490574 — Trial of Underwater Versus Gas-Insufflation Colorectal Endoscopic Submucosal DisseEtion · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05562596 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Roma La Sapienza
- Last refreshed: 3 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05562596.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing