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Effect of Inhalational Sedation on Mechanical Power in Mechanically Ventilated Patients: a Pilot Open-label Randomized Controlled Study
Analgosedation is usually given to critically ill patients admitted in ICU. Fentanyl is the most common agent used for this purpose. For sedative agent, midazolam and propofol are commonly administered. However, too much sedation is apparently associated with increased duration of mechanical ventilation, prolonged ICU stay, and increased mortality. In mechanically ventilated patients, mechanical power is the respiratory mechanic that can predict clinical outcomes including mortality in both ARDS and non-ARDS patients. Previous study demonstrated that sedating mechanically ventilated patients with propofol could decreased mechanical power. This was possibly associated with improved clinical outcomes in these patients. At present, there is no clinical study investigating effects of inhalation sedation on mechanical power and clinical outcomes in mechanically ventilated patients.
Details
| Lead sponsor | Mahidol University |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 40 |
| Start date | 2022-11-15 |
| Completion | 2024-04-30 |
Conditions
- Mechanical Ventilation
- Sedation
- Mechanical Power
- Lung Injury
- ICU
Interventions
- Inhalational sedation
- Convention sedation
Primary outcomes
- Change in mechanical power — At 15 hours after intervention applied
Change in mechanical power from Phase 1 to Phase 2 compared between 2 groups
Countries
Thailand