NCT05559684

Analgesic Efficacy of Bilateral US Guided TTPB vs ESPB in Pediatric Patients Undergoing Corrective Cardiac Surgeries

Completed NA Last updated 9 January 2024

What this trial tests

NA trial testing Erector spinae plane block in Pain, Postoperative in 30 participants. Completed in 14 September 2023.

Timeline

1 November 2022

Primary endpoint
14 September 2023

14 September 2023

Quick facts

Lead sponsor	Cairo University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	single
Primary purpose	health services research
Enrollment	30
Start date	1 November 2022
Primary completion	14 September 2023
Estimated completion	14 September 2023
Sites	1 location across Egypt

Drugs / interventions tested

• Erector spinae plane block — full drug profile →
• Transversus thoracis plane block

Conditions studied

• Pain, Postoperative — all drugs for Pain, Postoperative →

Sponsor

Cairo University

Who can join

Adults 6 Months to 4, any sex, with Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Corrective cardiac surgeries include a bundle of major surgeries that take place in pediatric patients and require imperative perioperative pain control; hence, the art of healing starts from trying to diminish or abolish pain.

The use of highly potent opioids for paediatric cardiac anaesthesia has gained widespread popularity during the last 20 years . In addition to the important advantage of hemodynamic stability, the large-dose opioid-based anaesthetic techniques also blunt the stress response; however, large doses can cause over sedation, respiratory depression and prolonged mechanical ventilation after surgery .

There are many ways to limit pain in such population with the topper potent opioids in the last several years. But new regional pain management modalities started to arise because of their known effect to diminish neuroendocrine stress response, provide excellent postoperative analgesia, and facilitate early postoperative extubation .

Of the new evolving methods, the bilateral Transversus Thoracic Muscle Plane Block (TTPB) provides analgesia to the anterior chest wall and proved to be efficient in pediatric patients undergoing cardiac surgery using a median sternotomy approach .

The bilateral Erector Spinae Plane Block (ESPB) is also one of the recently known pain controlling techniques used in pediatric cardiac surgeries. It became popular because it is much safer and easily administered than other alternative regional techniques as thoracic paravertebral and thoracic epidural block .

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Analgesic Efficacy of Bilateral Ultrasound-Guided Transversus Thoracic Muscle Plane Block Versus Erector Spinae Plane Block in Pediatric Patients Undergoing Corrective Cardiac Surgeries: A Randomized Controlled Study.
   Madkour MAFA, Abueldahab EIB, Elela AHA, Youssef MF, et al · · 2025 · cited 1× · PMID 40122711 · DOI 10.1053/j.jvca.2025.03.001