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NCT05556174: REMAIN-1
Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers
NA trial testing periodic lung recruitment maneuvers in Postoperative Complications in 1,060 participants. Completed in 11 November 2024.
11 September 2024
Quick facts
| Lead sponsor | Sixth Affiliated Hospital, Sun Yat-sen University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 1,060 |
| Start date | 9 October 2022 |
| Primary completion | 11 September 2024 |
| Estimated completion | 11 November 2024 |
| Sites | 1 location across China |
Drugs / interventions tested
- periodic lung recruitment maneuvers
Conditions studied
- Postoperative Complications — all drugs for Postoperative Complications →
- Abdominal Surgery — all drugs for Abdominal Surgery →
- Intraoperative Mechanical Ventilation — all drugs for Intraoperative Mechanical Ventilation →
Sponsor
Sixth Affiliated Hospital, Sun Yat-sen University
Who can join
18 and older, any sex, with Postoperative Complications or Abdominal Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postoperative Pulmonary Complications (PPC) are common. It severely affects postoperative recovery, particularly in abdominal surgery. Several studies showed that intraoperative lung-protective ventilation with periodic lung recruitment maneuvers could reduce postoperative pulmonary complications. Other studies showed that intraoperative lung protective ventilation without periodic lung recruitment maneuvers could also reduce postoperative pulmonary complications. The purpose of this study was to compare the effects of the above two regimens on postoperative pulmonary complications.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Intraoperative protective ventilation with or without periodic lung recruitment manoeuvres on pulmonary complications after major abdominal surgery (REMAIN-1): protocol for a randomised controlled trial.
Zhang NR, Zhang LZ, Chen Y, Zhang S, et al · · 2025 · cited 2× · PMID 40082005 · DOI 10.1136/bmjopen-2024-093360
Verify or expand the search:
- PubMed search for NCT05556174
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Sixth Affiliated Hospital, Sun Yat-sen University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05556174 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sixth Affiliated Hospital, Sun Yat-sen University
- Last refreshed: 3 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05556174.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing