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NCT05555771: DETECT-ED
Paediatric Syncope in the Emergency Department
NA trial testing Counterpressure Maneuvers in Syncope, Vasovagal in 300 participants. Currently enrolling.
30 September 2026
Quick facts
| Lead sponsor | Dr. Victoria Claydon |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 300 |
| Start date | 3 September 2022 |
| Primary completion | 30 September 2026 |
| Estimated completion | 30 September 2026 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Counterpressure Maneuvers
- Usual Care
Conditions studied
- Syncope, Vasovagal — all drugs for Syncope, Vasovagal →
- Postural Orthostatic Tachycardia Syndrome — all drugs for Postural Orthostatic Tachycardia Syndrome →
- Orthostatic Intolerance — all drugs for Orthostatic Intolerance →
Sponsor
Dr. Victoria Claydon
Who can join
Adults 6 to 18, any sex, with Syncope, Vasovagal or Postural Orthostatic Tachycardia Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients. Participants presenting to the emergency department (ED) will first provide written informed consent. In stage I, they will be asked to complete a brief survey documenting the presentation of their syncopal episode, and any prodromal symptoms they experienced. Participants that consent to the second stage of the study will either receive usual care (control arm) or training in counter pressure maneuvers alongside usual care (intervention arm; leg crossing, bending, arm tensing). These patients will be followed for one years time, and will be asked to complete monthly surveys detailing their syncopal and presyncopal recurrence. Medical records will be accessed over the duration of the study to identify any changes in medical diagnosis.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05555771
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Syncope, Vasovagal
Currently open trials in the same condition.
- NCT06159764 — National Registry of Cardioneuroablation in Recurrent Reflex Syncope · recruiting
- NCT06496074 — Heart Rate Variation in Females Predicts Tilt Test Results · active not recruiting
- NCT06472102 — Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography · NA · recruiting
- NCT06458140 — Cardioneuroablation and Ventricular Proarrhythmia · NA · recruiting
- NCT06440291 — Cardioneuroablation for Reflex Syncope and Exercise Capacity · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05555771 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dr. Victoria Claydon
- Last refreshed: 27 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05555771.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing