NCT05555693

Correlation Between Postoperative Cognitive-related Adverse Reactions and Brain Metabolomic Characteristics in Elderly Patients

Recruiting now Last updated 27 September 2022

What this trial tests

trial testing Collecting clinical data, EGG，Brain Metabolomic Characteristics(with Magnetic Resonance Spectroscopy), blood gas data and blood sample in POCD - Postoperative Cognitive Dysfunction in 200 participants. Currently enrolling.

Timeline

27 July 2022

Primary endpoint
1 January 2027

1 December 2027

Quick facts

Lead sponsor	Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	200
Start date	27 July 2022
Primary completion	1 January 2027
Estimated completion	1 December 2027
Sites	1 location across China

Drugs / interventions tested

• Collecting clinical data, EGG，Brain Metabolomic Characteristics(with Magnetic Resonance Spectroscopy), blood gas data and blood sample

Conditions studied

• POCD - Postoperative Cognitive Dysfunction — all drugs for POCD - Postoperative Cognitive Dysfunction →

Sponsor

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Who can join

65 and older, any sex, with POCD - Postoperative Cognitive Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Postoperative cognitive dysfunction (POCD) refers to the difficulties of orientation, cognition, communication, memory and abstract thinking of patients after anesthesia and surgery. And/or accompanied by the decline of the ability in social activities, such as the change of personality, social ability of language and behavior, cognitive function and life skills. POCD is a common complication of central nervous system in elderly patients after operation, with an early incidence of about 21% and a long-term incidence of about 35% . According to the current research on Alzheimer's disease (AD) and POCD in the elderly, it has been found that they have similar pathological basis and some homologous related genes. Altogether, POCD is closely related to molecular pathway neuropsychiatric diseases (such as dementia, depression and Alzheimer's disease). Researchers have come up with various hypotheses to reveal the underlying mechanisms of POCD, including neuritis, oxidative stress, autophagy disorder, synaptic dysfunction, and lack of neurotrophic support. To date, apart from evaluating with scales, CT Scan and EEG analysis, there is neither exact biomarkers for monitoring and diagnosing POCD, nor clear relationships between specific Brain Metabolomic Characteristics, EEG changes and diagnosis of POCD, so that the diagnosis of early POCD only stays in the evaluation of clinical symptoms and scales. Therefore, our study aims to provide an effective basis for early diagnosis and treatment of clinical POCD through multivariate analyses of clinical scales combined with Brain Metabolomic Characteristics, EEG analysis of patients.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The autophagy-senescence axis as a threshold model of aging and therapeutic targeting.
   Bahar ME, Hwang JS, Lai TH, Akter KM, et al · · 2026 · cited 2× · PMID 41690118 · DOI 10.1016/j.redox.2026.104079