Last reviewed · How we verify
NCT05555667: LOSREB
Long-term Sedation With Remimazolam Besylate in Critically Ill Patients
Phase 3 trial testing Remimazolam besylate in Light Sedation in 728 participants. Status unknown.
1 November 2025
Quick facts
| Lead sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
|---|---|
| Phase | Phase 3 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 728 |
| Start date | 16 May 2023 |
| Primary completion | 1 November 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- Remimazolam besylate — full drug profile →
- Propofol (Propofol) — full drug profile →
Conditions studied
- Light Sedation — all drugs for Light Sedation →
- Mechanical Ventilation — all drugs for Mechanical Ventilation →
Sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Who can join
Adults 18 to 80, any sex, with Light Sedation or Mechanical Ventilation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A randomized non-inferior trial comparing remimazolam besylate with propofol for long-term sedation during invasive mechanical ventilation in critically ill patients
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Long-term sedation with remimazolam besylate versus propofol in critically ill patients during invasive mechanical ventilation: a study protocol for a multicenter randomized non-inferior trial.
Yang X, Tang Y, Du R, Yu Y, et al · · 2023 · cited 4× · PMID 37576823 · DOI 10.3389/fphar.2023.1139872
Verify or expand the search:
- PubMed search for NCT05555667
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Remimazolam besylate
Trials testing the same drug.
- NCT07213544 — Remimazolam vs Propofol in Laser Burn Cases · Phase 4 · recruiting
- NCT07456111 — A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy · Phase 4 · recruiting
- NCT06427785 — The Effect of Wavelet Index in Monitoring the Sedation Depth of Remimazolam Besylate · not yet recruiting
- NCT06359834 — Comparison of Remimazolam and Propofol Effect on Oxygen Reserve During Endoscopic Retrograde Cholangiopancreatography · NA · completed
- NCT05975255 — Dose Finding Study for Remimazolam in Children · Phase 2 · unknown
Other Union Hospital, Tongji Medical College, Huazhong University of Science and Technology trials
Trials by the same sponsor.
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- NCT06970262 — FMT for Lung and Associated-organ Rescue Efficacy in ARDS Patients · NA · recruiting
- NCT07509424 — Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Lo · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05555667 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Last refreshed: 26 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05555667.
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