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NCT05554315
Speckle Plethysmography Pulse Transit Time as a Marker of Blood Pressure Changes
trial in Blood Pressure in 40 participants. Completed in 8 August 2025.
5 August 2025
Quick facts
| Lead sponsor | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 19 April 2023 |
| Primary completion | 5 August 2025 |
| Estimated completion | 8 August 2025 |
| Sites | 1 location across United States |
Conditions studied
- Blood Pressure — all drugs for Blood Pressure →
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Who can join
Adults 18 to 99, any sex, with Blood Pressure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: Blood pressure is one of the key markers of cardiovascular health. High blood pressure, also called hypertension, can increase the risk of heart disease or stroke. Monitoring a person s blood pressure continuously over a 24-hour period at home is the best way to diagnose hypertension, but the equipment currently used to do it is cumbersome. This natural history study will test a new technique for monitoring blood pressure continuously over time. Objective: To test a new technique (speckle plethysmography) for measuring blood pressure in healthy adults. Eligibility: Healthy people aged 18 years and older. Design: Participants will come to the clinic a minimum of 2 times. The screening visit will last up to 2 hours. Participants will have a physical exam. Their vital signs will be taken. The clinical visit will last up to 1 hour. Participants will recline in a chair. Sensors to measure the activity of the heart will be placed on their chest. Different sensors will be placed on two fingers and one big toe. A device to measure blood pressure will be placed on one arm. While wearing the sensors, participants will undergo 3 tests: They will be asked to breathe slowly for 2 minutes. They will be asked to solve a math problem. They will immerse one hand or foot into an ice bath for up to 2 minutes. Each test will be followed by a 5-minute recovery period. Participants may elect to return for up to 3 more visits during the following week.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05554315
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05554315 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Last refreshed: 27 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05554315.
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