Last reviewed · How we verify
NCT05552833: COPDEX0
Pulmonary Adaptive Responses to HIIT in COPD
NA trial testing High intensity interval training in Chronic Obstructive Pulmonary Disease in 24 participants. Status unknown.
1 August 2024
Quick facts
| Lead sponsor | Rigshospitalet, Denmark |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 24 |
| Start date | 5 September 2022 |
| Primary completion | 1 August 2024 |
| Estimated completion | 1 August 2024 |
| Sites | 2 locations across Denmark |
Drugs / interventions tested
- High intensity interval training
Conditions studied
- Chronic Obstructive Pulmonary Disease — all drugs for Chronic Obstructive Pulmonary Disease →
Sponsor
Rigshospitalet, Denmark
Who can join
Adults 45 to 80, any sex, with Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients with chronic obstructive lung disease (COPD) suffer from a progressive loss of lung function that leads to poor quality of life, and often invalidity and early death. Regular exercise can improve quality of life in these patients, but the health care system lack the underlying mechanism of exercise-induced improvement in COPD and it is widely thought not to have any effect on lung function. The aim of the present study is to investigate to which extent lung tissue mass and rest-to-exercise diffusion capacity changes differ in COPD patients compared to the healthy state. In order to design prospective clinical trials on the putative impact of high-intensity interval training (HIIT) investigating these parameters, and a secondary aim is to assess the feasibility of such a study in terms of patient inclusion, adherence and methodology.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Pulmonary adaptations to 12 wk of supervised high intensity interval training in COPD: a nonrandomized controlled pilot study.
Hartmann JP, Nymand SB, Hartmeyer HL, Andersen AB, et al · · 2025 · cited 3× · PMID 40411808 · DOI 10.1152/japplphysiol.00037.2025 -
Alveolar-capillary reserve in COPD assessed by the pulmonary diffusing capacity response to an upright-to-supine postural change.
Rasmussen IE, Nymand SB, Hartmann JP, Thomsen RS, et al · · 2026 · cited 1× · PMID 42185027 · DOI 10.1113/ep093384
Verify or expand the search:
- PubMed search for NCT05552833
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High intensity interval training
Trials testing the same drug.
- NCT07153523 — Effect of High Intensity Interval Training on Strength, Endurance and Flexibility · NA · recruiting
- NCT07328568 — Effect of Low Volume Sprint Interval Training on Cardiorespiratory Fitness · NA · active not recruiting
- NCT07025694 — Exercise Training Among Children With Cerebral Palsy to Increase Health and Well-being - A Feasibility Study · NA · recruiting
- NCT06509464 — Response Of Metabolic Syndrome Severity Score To High Intenisty Interval Training In Women With Central Obesity. · NA · recruiting
- NCT07046520 — Effects of HIIT on Plasma Volume and Aerobic Capacity in Obese Adolescent Girls · NA · completed
Other recruiting trials for Chronic Obstructive Pulmonary Disease
Currently open trials in the same condition.
- NCT06749262 — Inclined Versus Standard Exercise for COPD Patients · NA · recruiting
- NCT07406659 — Different Inspiratory Muscle Trainings in Patients With COPD · NA · recruiting
- NCT07051707 — Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD · NA · recruiting
- NCT07418736 — A Phase II Study of CM326 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease · Phase 2 · recruiting
- NCT07069829 — Study of Clinical and Patient-reported Outcomes in Adults With Moderate to Severe COPD Treated With Breztri/Trixeo · recruiting
Other Rigshospitalet, Denmark trials
Trials by the same sponsor.
- NCT07401368 — Clinicians' Trust in AI-Based Fetal Growth Estimates · NA · not yet recruiting
- NCT07442357 — The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial · NA · not yet recruiting
- NCT07528729 — Alcohol as a Modifiable Risk Factor for Atrial Fibrillation · NA · not yet recruiting
- NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
- NCT07467187 — Invasive Home Ventilation in Denmark · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05552833 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
- Last refreshed: 17 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05552833.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing