Superselective Adrenal Arterial Embolization for Resistant Hypertension

NCT05552300 NA UNKNOWN

Resistant hypertension (RH) is usually defined as blood pressure (BP) that remains above guideline-specified targets despite the use of three or more antihypertensive agents at optimal or maximally tolerated doses, with one of those agents preferably being a diuretic. It is not uncommon, being identified in 10 to 30% of hypertensive patients and it is known to be a risk factor for cardiovascular (CV) events, including stroke, myocardial infarction (MI), heart failure (HF), and CV mortality, as well as adverse renal events,including chronic kidney disease (CKD) and end-stage kidney disease (ESKD). The activation of the renin-angiotensin-aldosterone system (RAAS) and sympatho-adrenomedullary system can play a pathogenic role in triggering and sustaining RH. SAAE is a catheter-based percutaneous transluminal procedure which selectively injects ethanol into adrenal artery to ablate part of the adrenal gland for suppression of excessive aldosterone and catecholamines. Therefore, SAAE is a minimally invasive procedure that might be used as an alternative strategy to antihypertensive drugs or reduce the intensity of antihypertensive drugs.

Details

Lead sponsor	First Affiliated Hospital of Chengdu Medical College
Phase	NA
Status	UNKNOWN
Enrolment	144
Start date	Sat Oct 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Mar 31 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Resistant Hypertension

Interventions

• SAAE
• traditional triple antihypertensive treatment