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Preventing Recurrent UTI With Vaginal Estrogen (PRUVE)
Among postmenopausal women who suffer from recurrent urinary tract infections (UTI), vaginal estrogen therapy prevents UTI recurrences for 50% of sufferers. This research will investigate why some women benefit but others do not, focusing on (a) the effects of vaginal estrogen therapy on the bacteria that inhabit the vagina and bladder, (b) its influence on immune responses in both compartments, and (c) the extent to which those changes are critical to successful UTI prevention. The findings will be a first step in the development of more effective strategies to prevent UTI, one of the most common and costly benign urologic conditions.
Details
| Lead sponsor | Johns Hopkins University |
|---|---|
| Phase | PHASE4 |
| Status | COMPLETED |
| Enrolment | 27 |
| Start date | Sat Jan 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sun Aug 31 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Recurrent Urinary Tract Infection
- Urinary Tract Infections
- Cystitis Recurrent
Interventions
- Vaginal estradiol tablets
Countries
United States