Last reviewed · How we verify
NCT05549843
Manual Therapy in the Treatment of Hemophilic Arthropathy of the Ankle
NA trial testing Manual therapy in Hemophilia in 24 participants. Completed in 26 February 2023.
18 November 2022
Quick facts
| Lead sponsor | Investigación en Hemofilia y Fisioterapia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 24 |
| Start date | 14 October 2022 |
| Primary completion | 18 November 2022 |
| Estimated completion | 26 February 2023 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Manual therapy
Conditions studied
- Hemophilia — all drugs for Hemophilia →
Sponsor
Investigación en Hemofilia y Fisioterapia
Who can join
Adults 18 to 60, male only, with Hemophilia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Introduction: Hemophilic ankle arthropathy is manifested by degenerative functional alterations (deficit of muscle strength, mobility and proprioception), intra-articular alterations and chronic pain. Manual therapy techniques are used to treat soft tissue adhesions, relieve pain and reduce tissue sensitivity. Design. randomized pilot trial. Aimed: To evaluate the safety and effectiveness of a protocol by manual therapy techniques in patients with hemophilic ankle arthropathy. Patients: 24 patients with ankle arthropathy will be recruited for inclusion in the study. Patients will be recruited in seven centers, from different regions of Spain. Intervention: Each session will last approximately 50-60 minutes, with 1 physiotherapy session per week for a period of 3 weeks. Patients will be evaluated at baseline, after the intervention, and after a follow-up period of 3 weeks. The treatment program includes 10 exercises that must be administered bilaterally. Measuring instruments and study variables: Visual Analog Scale and pressure algometer (joint pain); Leg motion (ankle range of motion); and Haemophilia Joint Health Score (joint health). At the same time, the study will allow to determine joint bleeding caused by applied physiotherapy treatment. Expected results: To demonstrate the safety of this Physiotherapy technique in patients with hemophilia. Likewise, an improvement in ankle pain, joint motion, joint health and pressure pain threshold.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Joint and Myofascial Manual Therapy Techniques in Haemophilic Ankle Arthropathy: A Randomized Pilot Study.
Truque-Díaz C, Meroño-Gallut J, Cuesta-Barriuso R, Pérez-Llanes R. · · 2025 · cited 2× · PMID 39917949 · DOI 10.1111/hae.70002
Verify or expand the search:
- PubMed search for NCT05549843
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Manual therapy
Trials testing the same drug.
- NCT07518732 — Investigation of the Effect of Thoracic Manipulation and Classical Massage on Pain, Flexibility and Sleep Quality · NA · enrolling by invitation
- NCT07297251 — Temporomandibular Joints Mobility and Head Posture: Influence of Manual Therapy and Exercises in Dental Patients. · NA · not yet recruiting
- NCT06544395 — Efficacy of Non-invasive Neuromodulation Treatments for COVID-19 Sequelae · NA · not yet recruiting
- NCT07306312 — Psychological Predictors of Pain and Disability in Patients With Chronic Low Back Pain After Manual Therapy · NA · enrolling by invitation
- NCT07326475 — Comparison Interventions on Kinetic and Kinematic Parameters · NA · enrolling by invitation
Other recruiting trials for Hemophilia
Currently open trials in the same condition.
- NCT07579585 — Effects of Photobiomodulation in Hemophilia Patients. · NA · recruiting
- NCT07406139 — PCC Treatment for Hemophilia Patients With Inhibitor（2022PCC-A） · Phase 4 · recruiting
- NCT07285460 — A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male Participants Aged 1 to Less Than 12 Year · Phase 3 · recruiting
- NCT07187661 — Intra-Articular Bevacizumab for Preventing Recurrent Hemarthrosis in Hemophilia With Chronic Synovitis · NA · recruiting
- NCT07099313 — Association of Prophylactic Treatment With Treatment Burden and Psychosocial Variables in Patients With Hemophilia · recruiting
Other Investigación en Hemofilia y Fisioterapia trials
Trials by the same sponsor.
- NCT07516730 — Central Pain Mechanisms and Clinical and Psychological Factors Associated With Pain Interference in Daily Life in Adults · not yet recruiting
- NCT07483541 — Identification of Modifiable Sleep-related Factors in Patients With Systemic Lupus Erythematosus. · not yet recruiting
- NCT07420387 — Effectiveness of an Educational Program for Pain Management in Patients With Hemophilic Arthropathy · NA · not yet recruiting
- NCT07420348 — Incidence of Ultrasonographically Detected Articular Damage in Initially Healthy Joints of Patients With Hemophilia A Re · not yet recruiting
- NCT07123220 — Prognostic Factors for Fatigue in Patients With Systemic Lupus Erythematosus · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05549843 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Investigación en Hemofilia y Fisioterapia
- Last refreshed: 9 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05549843.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing