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NCT05548517: TREMBO
TRE: Microbiome, Metabolic Health and Bone
NA trial testing Time Restricted Eating (TRE) in Weight Loss in 49 participants. Completed in 15 September 2025.
15 August 2024
Quick facts
| Lead sponsor | Rutgers, The State University of New Jersey |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 49 |
| Start date | 15 October 2022 |
| Primary completion | 15 August 2024 |
| Estimated completion | 15 September 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Time Restricted Eating (TRE)
- Calorie Restriction
Conditions studied
- Weight Loss — all drugs for Weight Loss →
- Time Restricted Feeding — all drugs for Time Restricted Feeding →
- Bone Loss — all drugs for Bone Loss →
Sponsor
Rutgers, The State University of New Jersey
Who can join
Adults 50 to 79, female only, with Weight Loss or Time Restricted Feeding. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In the Time-Restricted Eating: Microbiome and Bone (TREMBO) study, the primary goal is to determine the effect of time-restricted eating with caloric restriction compared to caloric restriction alone on bone health, as well as body weight and the gut microbiota in older women who are overweight or obese.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Link Between the Gut Microbiome and Bone Metastasis.
Sevcikova A, Martiniakova M, Omelka R, Stevurkova V, et al · · 2024 · cited 5× · PMID 39596154 · DOI 10.3390/ijms252212086
Verify or expand the search:
- PubMed search for NCT05548517
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Time Restricted Eating (TRE)
Trials testing the same drug.
- NCT07262593 — Family-Based Meal Timing for Cancer Prevention Among Native Hawaiian and Other Pacific Islanders: FAMTIME · NA · terminated
- NCT05742165 — Time Restricted Eating for Weight Loss Maintenance · NA · completed
- NCT05860413 — Intermittent Fasting for the Treatment of Type 2 Diabetes Mellitus · NA · completed
- NCT04259632 — Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans · NA · completed
Other recruiting trials for Weight Loss
Currently open trials in the same condition.
- NCT06811324 — Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults · Phase 2 · recruiting
- NCT07223983 — Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS) · Phase 1 · recruiting
- NCT07213466 — Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder · Phase 4 · recruiting
- NCT06785064 — Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance · NA · recruiting
- NCT07165431 — Effect of a Postbiotic Supplementation in Overweight and Obese Subjects: A Randomized Controlled Trial (PARABIOTICS-2). · NA · recruiting
Other Rutgers, The State University of New Jersey trials
Trials by the same sponsor.
- NCT07243886 — Mobile-based Obstetric Monitoring for Pregnancies Complicated by Hypertension and/or Diabetes (MOM-HD) · NA · not yet recruiting
- NCT06955130 — Lactate and Glycerol Contribution to Gluconeogenesis · NA · not yet recruiting
- NCT06822010 — SeqUential GeMcitabine and MITomycin Treatment for Favorable High-Risk Upper Urinary Tract Urothelial Carcinoma · Phase 2 · not yet recruiting
- NCT07525011 — Comparative Study of Denture Fabrication Techniques · NA · not yet recruiting
- NCT06834204 — Advancing Care Coordination Between Cancer and Primary Care Teams for Complex Cancer Survivors · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05548517 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rutgers, The State University of New Jersey
- Last refreshed: 13 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05548517.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing