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NCT05546788
Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis
Phase 1 trial testing scaling and root planing in Inflammatory Disease in 30 participants. Status unknown.
20 November 2023
Quick facts
| Lead sponsor | Assiut University |
|---|---|
| Phase | Phase 1 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 20 October 2023 |
| Primary completion | 20 November 2023 |
| Estimated completion | 20 November 2023 |
Drugs / interventions tested
- scaling and root planing
- hydroxylated poly methoxy flavones — full drug profile →
- chlorhexidine (CHLORHEXIDINE) — full drug profile →
- placebo
Conditions studied
- Inflammatory Disease — all drugs for Inflammatory Disease →
- Periodontal Diseases — all drugs for Periodontal Diseases →
Sponsor
Assiut University
Who can join
Adults 20 to 50, any sex, with Inflammatory Disease or Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontitis is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth. Hydroxylated poly methoxy flavones are a combination of naturally occurring flavonoids extracted from the orange peel and exert anti-inflammatory, antibacterial, and antifungal activity however, this extract is poorly soluble and poorly absorbable. In this work, this extract was formulated as a solid dispersion formulation to enhance its biological activity and then incorporated into a gel base and used in the treatment of periodontitis after clinical debridement.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05546788
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Assiut University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05546788 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Assiut University
- Last refreshed: 10 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05546788.
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