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NCT05546021
Nociception Level Monitor (NOL) During Guided Analgesic Delivery in Breast Surgeries
NA trial testing NOL monitor in Anesthesia; Adverse Effect in 60 participants. Completed in 28 February 2024.
31 January 2024
Quick facts
| Lead sponsor | University of Southern Denmark |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 60 |
| Start date | 1 September 2023 |
| Primary completion | 31 January 2024 |
| Estimated completion | 28 February 2024 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- NOL monitor
Conditions studied
- Anesthesia; Adverse Effect — all drugs for Anesthesia; Adverse Effect →
- Breast Cancer — all drugs for Breast Cancer →
Sponsor
University of Southern Denmark
Who can join
Adults 18 to 80, female only, with Anesthesia; Adverse Effect or Breast Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To assess if perioperative consumption of opioids can be optimized with the assistance of a Nociception Level (NOL) monitor in breast surgery patients receiving pectoral and parasternal nerve blocks as supplementation to general anaesthesia. Hypothesis: 1. NOL monitor guidance optimizes perioperative analgesic consumption and postoperative length of stay and offers a better quality of recovery in breast surgery. 2. Intraoperative NOL monitoring can detect the efficacy of pectoralis and parasternal nerve blocks. 3. Incidence of persistent neuropathic pain after breast cancer surgery is lower in patients receiving lower doses of perioperative opioids.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Influence of Nociception Level Monitor (NOL)-Guided Analgesic Delivery on Perioperative Course in Breast Surgeries: A Randomized Controlled Trial.
Malachauskiene L, Bhavsar R, Bakke S, Keller J, et al · · 2024 · cited 1× · PMID 39768803 · DOI 10.3390/medicina60121921
Verify or expand the search:
- PubMed search for NCT05546021
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of NOL monitor
Trials testing the same drug.
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Other recruiting trials for Anesthesia; Adverse Effect
Currently open trials in the same condition.
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Other University of Southern Denmark trials
Trials by the same sponsor.
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- NCT07104292 — Pelvic Floor Muscle Training During Pregnancy · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05546021 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Southern Denmark
- Last refreshed: 31 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05546021.
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