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NCT05543239: RELAX
Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Radiotherapy-Related Neuropathic Pain
NA trial testing Transcutaneous Auricular Vagus Nerve Stimulation(TaVNS) in Neuropathic Pain in 116 participants. Status unknown.
1 November 2023
Quick facts
| Lead sponsor | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 116 |
| Start date | 16 September 2022 |
| Primary completion | 1 November 2023 |
| Estimated completion | 1 March 2024 |
| Sites | 4 locations across China |
Drugs / interventions tested
- Transcutaneous Auricular Vagus Nerve Stimulation(TaVNS)
- Sham Transcutaneous Auricular Vagus Nerve Stimulation(SS)
Conditions studied
- Neuropathic Pain — all drugs for Neuropathic Pain →
- Radiotherapy Side Effect — all drugs for Radiotherapy Side Effect →
Sponsor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Who can join
18 and older, any sex, with Neuropathic Pain or Radiotherapy Side Effect. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This multi-center, randomized, double-blind, sham-controlled trial aims to investigate the effect and safety of TaVNS in treating radiotherapy-related neuropathic pain.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Efficacy of transcutaneous auricular vagus nerve stimulation on radiotherapy-related neuropathic pain in patients with head and neck cancers (RELAX): protocol for a multicentre, randomised, double-blind, sham-controlled trial.
Zuo X, Li Y, Rong X, Yang X, et al · · 2023 · cited 6× · PMID 37730386 · DOI 10.1136/bmjopen-2023-072724 -
Efficacy and safety of transcutaneous auricular vagus nerve stimulation plus pregabalin for radiotherapy-related neuropathic pain in patients with head and neck cancer (RELAX): a phase 2 randomised trial.
Zuo X, Xu Y, Li S, Jiang J, et al · · 2025 · cited 4× · PMID 40697962 · DOI 10.1016/j.eclinm.2025.103345
Verify or expand the search:
- PubMed search for NCT05543239
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05543239 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Last refreshed: 12 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05543239.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing