Last reviewed · How we verify
NCT05539599
Comprehensive Ultrasound Evaluation as a Predictor of Weaning
trial testing Comprehensive evaluation in Mechanical Ventilation Weaning in 89 participants. Completed in 8 May 2024.
2 May 2024
Quick facts
| Lead sponsor | Università degli Studi di Ferrara |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 89 |
| Start date | 9 September 2022 |
| Primary completion | 2 May 2024 |
| Estimated completion | 8 May 2024 |
| Sites | 2 locations across Italy |
Drugs / interventions tested
- Comprehensive evaluation
Conditions studied
- Mechanical Ventilation Weaning — all drugs for Mechanical Ventilation Weaning →
- Weaning Failure — all drugs for Weaning Failure →
Sponsor
Università degli Studi di Ferrara — full company profile →
Who can join
Adults 18 to 90, any sex, with Mechanical Ventilation Weaning or Weaning Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Several studies investigated the role of specific clinical predictors of weaning success, but it is determined by a combination of different aspects that can result in success or failure. Indeed, unresolved lung disease, cardiac dysfunction, loss of respiratory and core muscle strength can play a role in a failure weaning to mechanical ventilation (MV). The investigators hypothesized that a combined score that include heart, lung, and respiratory muscle ultrasound (US) evaluation could be able to predict the ability of weaning success. Furthermore, it will be described weather the days of MV before weaning trial may affect the relevance of each clinical variable evaluated.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Integrated comprehensive assessment for predicting weaning success in difficult-to-wean critically ill patients: the WEAN-US study.
Fogagnolo A, Dres M, Murgolo F, Grasso S, et al · · 2026 · PMID 42243858 · DOI 10.1186/s13054-026-06113-7
Verify or expand the search:
- PubMed search for NCT05539599
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05539599 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Università degli Studi di Ferrara
- Last refreshed: 9 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05539599.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing