Last reviewed · How we verify
Clinical Study Evaluating the Safety of Lactobacillus Probiotic in Children With Drug Resistant Epilepsy
Animal and human studies have brought up evidence supporting Gut microbial disbalance, namely dysbiosis, as a causative factor of epilepsy, especially the refractory form. thus, probiotics might constitute a safe, low-cost, and effective supplementary therapy in patients with DRE. The Lactobacillus population is probiotic bacteria that have a beneficial role in epilepsy. Lactobacillus can influence brain function through the modulation of GABA, as shown in rodent models. Moreover, it has been demonstrated in animal models of epilepsy and in human epileptic patients that probiotic treatment aimed at restoring gut microbiota equilibrium has beneficial effects on epileptic symptoms by increasing GABA in animals and the levels of Bifidobacteria and Lactobacillus in humans.
Details
| Lead sponsor | Tanta University |
|---|---|
| Phase | PHASE2 |
| Status | COMPLETED |
| Enrolment | 60 |
| Start date | Sun Sep 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Feb 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Drug Resistant Epilepsy
Interventions
- Lactobacillus-Based Capsule
Countries
Egypt