Who is sponsoring NCT05536856?

NCT05536856 is sponsored by Al-Azhar University.

What condition does NCT05536856 study?

NCT05536856 studies Vitiligo, Topical Fluorouracil, Effervescent Mixture.

What drugs are being tested in NCT05536856?

Interventions: a new effervescent mixture 5-florouracil formula, 5-Fluorouracil plain powder.

What is the status of NCT05536856?

NCT05536856 is currently RECRUITING.

Last reviewed 2026-01-06 · How we verify

Topical 5-Fluorouracil Effervescent Powder in the Treatment of Vitiligo

NCT05536856 PHASE4 RECRUITING

A novel approach for 5-Fluorouracil delivery based on a solid effervescent formulation is proposed . 5-Fluorouracil is water soluble (\~50mg/ml) and therefore has been used for the development of novel topical formulations including nano and microparticles intended for skin targeting. After hydration 5-Fluorouracil could form a complex, a suspension or even be formulated to generate effervescence. In effervescent technology, gas bubbles occur from the liquid after chemical reaction between alkali salts and organic acids (mainly citric or tartaric. Due to liberation in CO2 gas, the dissolution of drug in water is enhanced. The aim of this study is the development and clinical evaluation of topical 5-florouracil effervescent powder formulation in the treatment of vitiligo.

Details

Lead sponsor	Al-Azhar University
Phase	PHASE4
Status	RECRUITING
Enrolment	60
Start date	Sat Oct 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Dec 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Vitiligo
Topical Fluorouracil
Effervescent Mixture

Interventions

a new effervescent mixture 5-florouracil formula
5-Fluorouracil plain powder

Countries

Egypt