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NCT05535049
Non-surgical Periodontal Treatment and Periostin Levels
NA trial testing Non-surgical periodontal treatment in Periodontal Treatment, Cytokines in 48 participants. Completed in 1 November 2021.
1 August 2021
Quick facts
| Lead sponsor | Mustafa Kemal University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 48 |
| Start date | 1 December 2019 |
| Primary completion | 1 August 2021 |
| Estimated completion | 1 November 2021 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Non-surgical periodontal treatment
Conditions studied
- Periodontal Treatment, Cytokines — all drugs for Periodontal Treatment, Cytokines →
Sponsor
Mustafa Kemal University
Who can join
Adults 24 to 58, any sex, with Periodontal Treatment, Cytokines. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Two different studies were planned from the recruited samples. The aim of these studies was to investigate the effect of non-surgical periodontal treatment on the inflammatory markers levels in serum and gingival crevicular fluid (GCF) in patients with periodontitis. There were two groups consisting of individuals who had periodontitis and those who were healthy, with 24 individuals in each group. Periostin levels were assessed at baseline, at the 24th h, 48th h, 14th day 1st month, 3rd month after non-surgical periodontal treatment in serum and GCF samples by the Elisa method in the first study. In parallel, interleukin 1 (IL)-beta and fibroblast growth factor levels were measured. Progranulin levels were assessed at baseline, at the 24th h, 48th h, 14th day 1st month, 3rd month after non-surgical periodontal treatment in serum and GCF samples by the Luminex method in the second study. In parallel, vascular endothelial growth factor, IL-1 beta, tumor necrosis factor-alpha, and IL-10 levels were measured.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The effect of non-surgical periodontal treatment on progranulin levels.
Sari A, Santamaria P, Nibali L. · · 2026 · PMID 40853679 · DOI 10.1002/jper.11396
Verify or expand the search:
- PubMed search for NCT05535049
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05535049 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mustafa Kemal University
- Last refreshed: 11 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05535049.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing