NCT05531019

COVID-19 Sequelae: Treatment and Monitoring. A Dietary Supplement Based on Sea Urchin Eggs With Echinochroma A

Completed NA Last updated 28 February 2023

What this trial tests

NA trial testing Echinochrome A in Long COVID in 54 participants. Completed in 18 December 2022.

Timeline

22 September 2021

Primary endpoint
8 December 2022

18 December 2022

Quick facts

Lead sponsor	Fernando Saldarini
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	54
Start date	22 September 2021
Primary completion	8 December 2022
Estimated completion	18 December 2022
Sites	1 location across Argentina

Drugs / interventions tested

• Echinochrome A
• Control

Conditions studied

• Long COVID — all drugs for Long COVID →

Sponsor

Fernando Saldarini

Who can join

Adults 18 to 60, any sex, with Long COVID. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to assess the efficacy and efficiency of a nutraceutical from sea urchin eggs with Echinochrome A in the inflammation of tissues in subjects with long Corona Virus (COVID) syndome

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Biological mechanisms underpinning the development of long COVID.
   Perumal R, Shunmugam L, Naidoo K, Wilkins D, et al · · 2023 · cited 26× · PMID 37265584 · DOI 10.1016/j.isci.2023.106935
2. Clinical Implications of COVID-19-Related Endothelial Dysfunction.
   Aljadah M, Khan N, Beyer AM, Chen Y, et al · · 2024 · cited 20× · PMID 39055276 · DOI 10.1016/j.jacadv.2024.101070
3. Post-COVID Condition and Neuroinflammation: Possible Management with Antioxidants.
   Cárdenas-Rodríguez N, Ignacio-Mejía I, Mejía-Barradas CM, Ortega-Cuellar D, et al · · 2025 · cited 2× · PMID 40722944 · DOI 10.3390/antiox14070840
4. EuroQol-5D-3L in Long Covid Patients After Supplementation with EchA Marine®, a Sea Urchin Eggs Extract: a double-blinded, multicentrical randomized trial.
   Brichetti V, Rubilar T, T J, Montecino P, et al · · 2023 · DOI 10.21203/rs.3.rs-3010169/v1
5. EuroQol-5D-3L in Long Covid patients After Supplementation with EchA Marine^®, a Sea Urchin Eggs Extract: a double-blinded, multicentrical study
   Brichetti V, Rubilar T, Tejada J, Montecino P, et al · · 2023 · DOI 10.1101/2023.05.31.23290798
6. EuroQol-5D-3L in Long Covid patients After Supplementation with EchA Marine®, a Sea Urchin Eggs Extract: a double-blinded, multicentrical study.
   V B, T R, J T, P M, et al · · 2023 · DOI 10.21203/rs.3.rs-3009885/v1