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NCT05529420: DurAct
Interindividual Variability in Duration of Action of Rocuronium in Pediatric Patients
trial testing measurement of the depth of neuromuscular blockade in Muscle Relaxation in 107 participants. Completed in 1 September 2023.
31 August 2023
Quick facts
| Lead sponsor | Brno University Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 107 |
| Start date | 5 September 2022 |
| Primary completion | 31 August 2023 |
| Estimated completion | 1 September 2023 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- measurement of the depth of neuromuscular blockade
Conditions studied
- Muscle Relaxation — all drugs for Muscle Relaxation →
Sponsor
Brno University Hospital
Who can join
Under 18, any sex, with Muscle Relaxation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Muscle relaxants represent an important part of general anesthesia in adult and pediatric patients. Their role is to facilitate intubation and enable some surgical interventions. At our workplace, monitoring of the depth of neuromuscular blockade is a standard procedure in accordance with the 2017 recommendation of ČSARIM entitled "Principles of Patient Safety in Anesthesiology" \[1,2\]. At present, we mainly use rocuronium. One of the advantages of this non-depolarizing steroidal muscle relaxant with a rapid onset and intermediate duration of action is the existence of the specific antagonist sugammadex.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Interindividual Variability in Duration of Action of Rocuronium in Paediatric Patients (DurAct): A Prospective Observational Study.
Szturzova K, Zelinkova H, Knoppova L, Toukalkova M, et al · · 2026 · PMID 41597113 · DOI 10.3390/children13010105
Verify or expand the search:
- PubMed search for NCT05529420
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Muscle Relaxation
Currently open trials in the same condition.
- NCT06707532 — The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA) · NA · recruiting
- NCT05736744 — Effect of Magnesium Sulphate Pretreatment in Pediatric Abdominal Surgery · Phase 2, PHASE3 · recruiting
Other Brno University Hospital trials
Trials by the same sponsor.
- NCT07468006 — Comparison of Transcutaneous and Blood CO₂ Measurement in Critically Ill Children · recruiting
- NCT07280039 — Mortality and Muscle Mass Loss in Critically Ill Patients. · not yet recruiting
- NCT07279701 — The Effect of Near-infrared Spectroscopy on the Success of Peripheral Venous Access · NA · recruiting
- NCT07245654 — Monitoring the Depth of Anesthesia and Nociception During the Induction of General Anesthesia in Pediatric Patients · recruiting
- NCT07110012 — The Role of Simulation-based Training in Resident Curriculum in Anaesthesia and Intensive Care · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05529420 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brno University Hospital
- Last refreshed: 21 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05529420.
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