NCT05527899 (ZIPP) is a Phase 2, PHASE3 clinical trial of Zinc gluconate in Zinc Deficiency, sponsored by Tufts University.

Who is sponsoring NCT05527899?

NCT05527899 is sponsored by Tufts University.

What drugs are being tested in NCT05527899?

Interventions in NCT05527899: Zinc gluconate.

What condition does NCT05527899 study?

NCT05527899 studies Zinc Deficiency.

Is NCT05527899 still recruiting?

NCT05527899 is currently completed. Last updated 30 July 2024.

Last reviewed 2024-07-30 · How we verify

NCT05527899: ZIPP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Zinc Intervention in Elderly for Prevention of Pneumonia

Completed Phase 2, PHASE3 Last updated 30 July 2024

What this trial tests

Phase 2, PHASE3 trial testing Zinc gluconate in Zinc Deficiency in 105 participants. Completed in 30 June 2024.

Timeline

3 May 2022

Primary endpoint
30 June 2024

30 June 2024

Quick facts

Lead sponsor	Tufts University
Phase	Phase 2, PHASE3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	105
Start date	3 May 2022
Primary completion	30 June 2024
Estimated completion	30 June 2024
Sites	1 location across United States

Drugs / interventions tested

Zinc gluconate — full drug profile →

Conditions studied

Zinc Deficiency — all drugs for Zinc Deficiency →

Sponsor

Tufts University

Who can join

65 and older, any sex, with Zinc Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Pneumonia is a major public health problem for the elderly and is one of the leading causes of hospitalization and death for this population, particularly for elderly nursing home residents. This planning grants seeks to establish a safe and effective dose of zinc supplementation with the goal to conduct a larger randomized clinical trial to study the effect of zinc supplementation in nursing home elderly with low serum zinc levels on the risk, antibiotic use, and duration of sick days with pneumonia. This project has significant potential to positively impact the health and quality of life in the elderly and to reduce the economic costs associated with their care.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Study protocol for a zinc intervention in the elderly for prevention of pneumonia, a randomized, placebo-controlled, double-blind clinical pilot trial.
Ortega EF, Wu D, Guo W, Meydani SN, et al · · 2024 · cited 1× · PMID 38450236 · DOI 10.3389/fnut.2024.1356594
The Role of Zinc Against Bacterial Infections in Neonates, Children, and Adults: A Scoping Review from the Available Evidence of Randomized Controlled Trials About Zinc Supplementation to New Research Opportunities.
De Rose DU, Mirotta N, Dotta A, Salvatori G, et al · · 2026 · PMID 41594103 · DOI 10.3390/antibiotics15010066

Verify or expand the search:

Other trials of Zinc gluconate

Trials testing the same drug.

NCT06120140 — Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small · Phase 2 · recruiting
NCT05098678 — Zinc Supplementation and Behçet's Syndrome · NA · completed
NCT03957720 — The Individual Therapy for Patients With Wilson's Disease · EARLY_PHASE1 · unknown
NCT05096312 — Effects of Oral Zinc Gluconate Among Acne Vulgaris Patients · Phase 4 · completed

Other recruiting trials for Zinc Deficiency

Currently open trials in the same condition.

NCT06219525 — Higher and Standard Doses of Enteral Zinc Supplementation in Very Preterm Infants · NA · recruiting
NCT05236374 — Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc · NA · recruiting
NCT04694235 — Egg Intervention During Pregnancy in Indonesia · NA · active not recruiting

Other Tufts University trials

Trials by the same sponsor.

NCT07249242 — Healing Outcomes of Peri-implant Soft Tissues With Different Healing Abutments · NA · recruiting
NCT07099131 — Effective Interventions to Overcome Severe Gag Reflex · EARLY_PHASE1 · not yet recruiting
NCT06428630 — Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus · EARLY_PHASE1 · withdrawn
NCT06526221 — Evaluating Urine Isoniazid Testing to Detect Nonadherence to Tuberculosis Medications in India · NA · not yet recruiting
NCT06352645 — Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05527899 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tufts University
Last refreshed: 30 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05527899.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing