Last reviewed · How we verify
NCT05525923
Personalized Postoperative Pain Management Following Thoracic Surgery in Adults
trial in Thoracic Surgery in 200 participants. Currently enrolling.
1 March 2026
Quick facts
| Lead sponsor | OpalGenix, Inc |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 30 November 2023 |
| Primary completion | 1 March 2026 |
| Estimated completion | 1 March 2028 |
| Sites | 4 locations across United States |
Conditions studied
- Thoracic Surgery — all drugs for Thoracic Surgery →
- Pneumonectomy — all drugs for Pneumonectomy →
- Lobectomy — all drugs for Lobectomy →
- Segmentectomy — all drugs for Segmentectomy →
Sponsor
OpalGenix, Inc — full company profile →
Who can join
Adults 18 to 99, any sex, with Thoracic Surgery or Pneumonectomy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone, in adults following thoracic surgery. Major inpatient thoracic surgeries (TS) for lung disease are common and extremely painful surgeries and are associated with sever post-surgical pain, high incidence of chronic post-surgical pain (CPSP), excess opioid use, costly immediate postoperative opioid adverse events (AEs), and long hospital stays. This study is aiming to develop proactive risk prediction algorithms for precision surgical pain relief in adult TS patients through comparison of actual clinical outcomes with standard of care to predicted outcomes based on personalized risk assessments.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Role of Pharmacogenetic Biomarkers in Pain.
Martin da Silva I, Plaza-Díaz A, Ruiz-Ramos J, Juanes-Borrego A, et al · · 2025 · cited 1× · PMID 40868188 · DOI 10.3390/biomedicines13081935
Verify or expand the search:
- PubMed search for NCT05525923
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Thoracic Surgery
Currently open trials in the same condition.
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- NCT07063602 — Sensory Anesthesia Achieved Through Different Paravertebral Block Approaches for Post-Op Pain Management After VATS Lung · recruiting
- NCT06732193 — Fissios© and Postoperative Complications (FPoC Trial) · NA · recruiting
- NCT06417996 — Biobeat Digital Home Monitoring Feasibility · NA · recruiting
Other OpalGenix, Inc trials
Trials by the same sponsor.
- NCT05452694 — OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05525923 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by OpalGenix, Inc
- Last refreshed: 1 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05525923.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing