NCT05524870

The Effect of Manual Therapy on Central Sensitization

Completed NA Last updated 18 November 2023

What this trial tests

NA trial testing Mobilization in Subacromial Pain Syndrome in 63 participants. Completed in 5 February 2023.

Timeline

15 February 2022

Primary endpoint
1 February 2023

5 February 2023

Quick facts

Lead sponsor	Cukurova University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	63
Start date	15 February 2022
Primary completion	1 February 2023
Estimated completion	5 February 2023
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Mobilization

Conditions studied

• Subacromial Pain Syndrome — all drugs for Subacromial Pain Syndrome →
• Central Sensitisation — all drugs for Central Sensitisation →

Sponsor

Cukurova University

Who can join

Adults 18 to 65, any sex, with Subacromial Pain Syndrome or Central Sensitisation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Subacromial pain syndrome (SIS) is a common cause of shoulder pain, estimated to be the cause for up to half of incident cases. Typically, pain is generated with elevation of the arm above the head though it can occur with rest in patients with SIS.There is evidence of central sensitization in those who experience chronic shoulder pain from SIS. Central sensitization is an augmentation of the nociceptive pathways of the central nervous system that is characterized by local and generalized lowered pain thresholds and an exaggerated pain response to painful and non painful stimulation.Mobilization with movement (MWM) technic is a kind of manual therapy and it is often used by clinicians for the treatment of musculoskeletal diseases. Usually manual therapy is used for its peripheral effects, however it also produces central analgesic effects activating descending anti-nociceptive pathways for a short period of time (30 - 35 mins.). Some speculate that repeated sessions of manual therapy may result in a long term activation of descending anti-nociceptive pathways. However, there is no evidence of this mechanism available yet. Therefore, the aim of this study is to investigate the effect of MWM on central sensitization (primary aim) and shoulder functions (secondary aim) in patients with SIS.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Mobilization with movement plus exercise versus exercise alone for patients with central sensitization associated with chronic subacromial pain syndrome: a sham-controlled randomized clinical trial.
   Deniz V, Kelle B. · · 2025 · PMID 40722073 · DOI 10.1186/s12906-025-05028-0