NCT05521763

Influenza Vaccine Uptake Among Healthcare Workers

Status unknown NA Last updated 15 September 2022

What this trial tests

NA trial testing ensuring the availability of influenza vaccine supply & developing influenza vaccine awareness in Influenza Vaccines in 3,000 participants. Status unknown.

Timeline

12 March 2022

Primary endpoint
29 December 2022

12 February 2023

Quick facts

Lead sponsor	International Centre for Diarrhoeal Disease Research, Bangladesh
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	3,000
Start date	12 March 2022
Primary completion	29 December 2022
Estimated completion	12 February 2023
Sites	1 location across Bangladesh

Drugs / interventions tested

• ensuring the availability of influenza vaccine supply & developing influenza vaccine awareness

Conditions studied

• Influenza Vaccines — all drugs for Influenza Vaccines →

Sponsor

International Centre for Diarrhoeal Disease Research, Bangladesh — full company profile →

Who can join

Eligibility, any sex, with Influenza Vaccines. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

1. Burden: Health-care workers (HCWs), such as doctors, nurses, and support staff involved in direct or indirect patient care, are at increased risk of influenza virus infections. HCWs may also transmit and spread influenza among hospitalized patients and other caregivers. HCWs often (40-83%) work while experiencing influenza-like illness (ILI), increasing the likelihood of influenza transmission to colleagues and patients.
2. Knowledge gap: Despite the World Health Organization recommendation for seasonal influenza vaccination among priority target groups such as health care workers, the low-income country such as Bangladesh lacks a seasonal influenza vaccination policy among this high-risk group, and vaccine uptake remains low.
3. Relevance: This study aims to generate preliminary data on HCWs willingness to get seasonal influenza vaccines following vaccine availability and factors associated with vaccine uptakes. The data from the study will support policymakers to increase awareness and develop influenza vaccination policy among top priority groups such as health care workers.

Hypothesis: The investigators hypothesize that awareness and availability of influenza vaccine supply would increase influenza vaccine uptake among health care workers

Objectives:

1. To assess influenza vaccine uptake among healthcare workers (HCWs) following awareness and availability of influenza vaccine supply in study hospitals
2. To explore HCWs barriers and Motivators for influenza vaccine uptake
3. To understand policy makers' perspectives on the feasibility of influenza vaccination among HCWs and to share with the National Immunization Technical Advisory Group (NITAG) for a policy decision regarding influenza vaccination

Methods:

The study will be conducted at four tertiary-level public teaching hospitals in Bangladesh. The investigators will use a cluster randomized controlled trial design. The intervention will be randomly allocated at the facility level and will include four arms: i) availability of influenza vaccine supply; ii) influenza vaccine awareness; iii) both influenza vaccine supply and influenza vaccine awareness, and iv) control arm with no intervention. The investigators will assess influenza vaccine uptake before and after intervention and between different study arms. The investigators will also explore the barriers and motivators of vaccine uptake using a qualitative approach. To understand the policy makers' perspectives and opinions regarding influenza vaccination among health care workers, the investigators will conduct in-depth interviews.

Outcome measures/variables:

1. The proportion of influenza vaccine uptake among health care workers before and after intervention and between different study arms
2. Different motivators and barriers to influenza vaccine uptake

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Seasonal influenza vaccine uptake among healthcare workers in tertiary care hospitals, Bangladesh: Study protocol for influenza vaccine supply and awareness intervention.
   Hassan MZ, Shirin T, Rahman M, Alamgir ASM, et al · · 2022 · cited 7× · PMID 36153529 · DOI 10.1186/s12889-022-14182-w
2. Physicians' Intentions to Recommend Influenza Vaccine: A Multi-Centered Hospital-Based Study Using the Theory of Planned Behavior in Bangladesh.
   Biswas MAAJ, Rahman M, Khan SH, Basher AK, et al · · 2025 · cited 2× · PMID 39857537 · DOI 10.3390/ijerph22010084