NCT05521477 (HISTEPPA) is a NA clinical trial of SLAB51 in Alzheimer Disease, sponsored by University Hospital, Geneva.

Who is sponsoring NCT05521477?

NCT05521477 is sponsored by University Hospital, Geneva.

What drugs are being tested in NCT05521477?

Interventions in NCT05521477: SLAB51.

What condition does NCT05521477 study?

NCT05521477 studies Alzheimer Disease.

Is NCT05521477 still recruiting?

NCT05521477 is currently completed. Last updated 23 January 2025.

Last reviewed 2025-01-23 · How we verify

NCT05521477: HISTEPPA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dynamic Response to Probiotics in Context of Alzheimer Disease: a Proof-of-concept Study

Completed NA Last updated 23 January 2025

What this trial tests

NA trial testing SLAB51 in Alzheimer Disease in 3 participants. Completed in 28 February 2024.

Timeline

1 September 2022

Primary endpoint
28 February 2024

28 February 2024

Quick facts

Lead sponsor	University Hospital, Geneva
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	3
Start date	1 September 2022
Primary completion	28 February 2024
Estimated completion	28 February 2024
Sites	1 location across Switzerland

Drugs / interventions tested

SLAB51

Conditions studied

Alzheimer Disease — all drugs for Alzheimer Disease →

Sponsor

University Hospital, Geneva

Who can join

Adults 60 to 80, any sex, with Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

proof-of-concept study to adequately design a larger trial to investigate the effect of supplementation of a probiotic (SLAB51) on AD biomarker.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects.
Li C, Peng K, Xiao S, Long Y, et al · · 2023 · cited 109× · PMID 37773196 · DOI 10.1038/s41420-023-01666-w
The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer's Disease Treatment.
Knight E, Geetha T, Broderick TL, Babu JR. · · 2023 · cited 9× · PMID 36984879 · DOI 10.3390/metabo13030438
The gut microbiota influences neurodegenerative diseases through the gut-brain axis: molecular mechanisms and effects on immune function.
Yang J, Song X, Yan S, Li Q, et al · · 2025 · PMID 41601624 · DOI 10.3389/fimmu.2025.1739329

Verify or expand the search:

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Other University Hospital, Geneva trials

Trials by the same sponsor.

NCT07506356 — Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors · recruiting
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NCT07173348 — Hypnosis on Breathlessness Mastery in Patients With Persistent Dyspnea · NA · not yet recruiting
NCT07129655 — Cholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Ch · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05521477 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Geneva
Last refreshed: 23 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05521477.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing