NCT05520086 (CELOPHIN) is a Phase 1, PHASE2 clinical trial of Single Dose in Chronic Conjunctivitis, sponsored by Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz.

Who is sponsoring NCT05520086?

NCT05520086 is sponsored by Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz.

What drugs are being tested in NCT05520086?

Interventions in NCT05520086: Single Dose, Double Dose.

What condition does NCT05520086 study?

NCT05520086 studies Chronic Conjunctivitis, Stevens-Johnson Syndrome, Lyell Syndrome, Pemphigoid.

Is NCT05520086 still recruiting?

NCT05520086 is currently status unknown. Last updated 8 July 2024.

Last reviewed 2024-07-08 · How we verify

NCT05520086: CELOPHIN

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Trial to Evaluate Safety and Efficacy of Cell Therapy in Patients With Cicatricial Conjuntivitis.

Status unknown Phase 1, PHASE2 Last updated 8 July 2024

What this trial tests

Phase 1, PHASE2 trial testing Single Dose in Chronic Conjunctivitis in 20 participants. Status unknown.

Timeline

11 November 2022

Primary endpoint
11 June 2024

11 November 2024

Quick facts

Lead sponsor	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Phase	Phase 1, PHASE2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	11 November 2022
Primary completion	11 June 2024
Estimated completion	11 November 2024
Sites	8 locations across Spain

Drugs / interventions tested

Single Dose
Double Dose — full drug profile →

Conditions studied

Chronic Conjunctivitis — all drugs for Chronic Conjunctivitis →
Stevens-Johnson Syndrome — all drugs for Stevens-Johnson Syndrome →
Lyell Syndrome — all drugs for Lyell Syndrome →
Pemphigoid — all drugs for Pemphigoid →

Sponsor

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz — full company profile →

Who can join

18 and older, any sex, with Chronic Conjunctivitis or Stevens-Johnson Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A phase IIa, open label, non controlled clinical trial to assess the feasibility and safety of allogeneic adipose-derived mesenchymal stem cells (ASC) in the treatment of cicatricial conjunctivitis associated with Lyell's syndrome, Stevens-Johnson's syndrome and mucous membrane pemphigoid with ocular involvement

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Current advancements in cellular immunotherapy for autoimmune disease.
Berry CT, Frazee CS, Herman PJ, Chen S, et al · · 2025 · cited 15× · PMID 39821376 · DOI 10.1007/s00281-024-01034-5
Biomedical Application of MSCs in Corneal Regeneration and Repair.
De Miguel MP, Cadenas-Martin M, Stokking M, Martin-Gonzalez AI. · · 2025 · cited 7× · PMID 39859409 · DOI 10.3390/ijms26020695
Human retinal secretome: A cross-link between mesenchymal and retinal cells.
Donato L, Scimone C, Alibrandi S, Scalinci SZ, et al · · 2023 · cited 6× · PMID 37545752 · DOI 10.4252/wjsc.v15.i7.665

Verify or expand the search:

Other Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz trials

Trials by the same sponsor.

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NCT06163807 — Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05520086 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Last refreshed: 8 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05520086.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing