NCT05518890 is a NA clinical trial of Diet Only in Knee Osteoarthritis, sponsored by University of Bath.

Who is sponsoring NCT05518890?

NCT05518890 is sponsored by University of Bath.

What drugs are being tested in NCT05518890?

Interventions in NCT05518890: Diet Only, Diet plus Exercise.

What condition does NCT05518890 study?

NCT05518890 studies Knee Osteoarthritis.

Is NCT05518890 still recruiting?

NCT05518890 is currently status unknown. Last updated 29 August 2022.

Last reviewed 2022-08-29 · How we verify

NCT05518890

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Energy Restriction and Exercise for Knee Osteoarthritis

Status unknown NA Last updated 29 August 2022

What this trial tests

NA trial testing Diet Only in Knee Osteoarthritis in 32 participants. Status unknown.

Timeline

1 January 2022

Primary endpoint
1 August 2023

1 August 2023

Quick facts

Lead sponsor	University of Bath
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	32
Start date	1 January 2022
Primary completion	1 August 2023
Estimated completion	1 August 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

Diet Only
Diet plus Exercise

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

University of Bath

Who can join

Adults 45 to 69, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators are looking at the effects of energy restriction, with or without exercise on markers of inflammation in individuals with knee osteoarthritis. There will be a 4 week 'wash-in' period where participants will maintain their normal lifestyle, followed by a 4 week 'intervention period' where participants will be randomised into either the diet alone group or the diet plus exercise group.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Exercise for osteoarthritis of the knee.
Lawford BJ, Hall M, Hinman RS, Van der Esch M, et al · · 2024 · cited 37× · PMID 39625083 · DOI 10.1002/14651858.cd004376.pub4
The effects of short-term dietary calorie restriction combined with aerobic exercise on systemic inflammation in overweight or obese individuals with knee osteoarthritis: a randomised controlled trial.
Deere R, Farrow M, Spellanzon B, Chowdhury E, et al · · 2026 · PMID 41759492 · DOI 10.1016/j.msksp.2026.103505

Verify or expand the search:

Other trials of Diet Only

Trials testing the same drug.

NCT03187028 — Diet and Exercise After Pancreatic Cancer · NA · completed
NCT02681601 — Nutrition Support to Improve Outcomes in Patients With Unresectable Pancreatic Cancer · NA · terminated
NCT05622149 — Is Strength Training a Viable Exercise Modality for Fat Loss? · NA · completed
NCT01516879 — Durable Effect of PCSK9 Antibody CompARed wiTh placEbo Study · Phase 3 · completed

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other University of Bath trials

Trials by the same sponsor.

NCT07360249 — Glucose-fructose Ratio Pilot · NA · recruiting
NCT06967077 — Exploring the Feasibility and Acceptability of Virtual Reality Exercise for Pain Management, Fear of Movement, Mobility, · NA · not yet recruiting
NCT07472244 — Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation? · NA · recruiting
NCT07099911 — Neuromuscular Electrical Stimulation and Glucose Control in Spinal Cord Injury · NA · recruiting
NCT07027553 — Remote Exercise to Improve Physical Activity Levels and Markers of Heart Health in Cystic Fibrosis (RHH-CF) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05518890 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Bath
Last refreshed: 29 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05518890.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing