NCT05514821 is a NA clinical trial of Beet It Sport Shot in Blood Pressure, sponsored by Newcastle University.

Who is sponsoring NCT05514821?

NCT05514821 is sponsored by Newcastle University.

What drugs are being tested in NCT05514821?

Interventions in NCT05514821: Beet It Sport Shot, Beet It Sport Shot Placebo.

What condition does NCT05514821 study?

NCT05514821 studies Blood Pressure.

Is NCT05514821 still recruiting?

NCT05514821 is currently completed. Last updated 5 December 2023.

Last reviewed 2023-12-05 · How we verify

NCT05514821

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Inter-individual Variation in the Blood Pressure Lowering Effects of Dietary Nitrate

Completed NA Last updated 5 December 2023

What this trial tests

NA trial testing Beet It Sport Shot in Blood Pressure in 15 participants. Completed in 25 September 2023.

Timeline

15 October 2022

Primary endpoint
25 September 2023

25 September 2023

Quick facts

Lead sponsor	Newcastle University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	treatment
Enrollment	15
Start date	15 October 2022
Primary completion	25 September 2023
Estimated completion	25 September 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

Beet It Sport Shot
Beet It Sport Shot Placebo

Conditions studied

Blood Pressure — all drugs for Blood Pressure →

Sponsor

Newcastle University

Who can join

Adults 18 to 45, male only, with Blood Pressure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Dietary nitrate supplementation, often in the form of beetroot juice, has been shown to lower blood pressure and could play a role in preventing or treating hypertension. However, it is currently unclear: a) how reproducible this response is within the same individual on different occasions, and b) whether there are genuine individual differences in the blood pressure lowering effects of dietary nitrate. This study will use a novel replicated cross-over design (2 x nitrate conditions, 2 x placebo conditions) to examine the reproducibility and inter-individual variability in the blood pressure lowering effects of dietary nitrate supplementation.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial.
Hayes E, Alhulaefi S, Siervo M, Whyte E, et al · · 2025 · cited 8× · PMID 39992469 · DOI 10.1007/s00394-025-03616-x
Inter-individual differences in the blood pressure lowering effects of dietary nitrate: A randomised double-blind placebo-controlled replicate crossover trial
Hayes E, Alhulaefi S, Siervo M, Whyte E, et al · · 2024 · DOI 10.1101/2024.12.02.24318286

Verify or expand the search:

Other trials of Beet It Sport Shot

Trials testing the same drug.

NCT04103736 — The Effect of Dietary Nitrates on Physical Performance and Vascular Function in Chronic Kidney Disease · NA · completed

Other recruiting trials for Blood Pressure

Currently open trials in the same condition.

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NCT07319117 — Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure. · NA · recruiting
NCT06837181 — Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM) · recruiting

Other Newcastle University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05514821 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Newcastle University
Last refreshed: 5 December 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05514821.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing