Who is sponsoring NCT05507710?

NCT05507710 is sponsored by Leiden University Medical Center.

What drugs are being tested in NCT05507710?

Interventions in NCT05507710: Near-infrared fluorescence imaging of perfusion.

What condition does NCT05507710 study?

NCT05507710 studies Fat Necrosis.

Is NCT05507710 still recruiting?

NCT05507710 is currently status unknown. Last updated 19 August 2022.

Last reviewed 2022-08-19 · How we verify

NCT05507710: FAFI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Indocyanine Green for Perfusion Assessment of DIEP Flaps

Status unknown Phase 3 Last updated 19 August 2022

What this trial tests

Phase 3 trial testing Near-infrared fluorescence imaging of perfusion in Fat Necrosis in 280 participants. Status unknown.

Timeline

1 May 2019

Primary endpoint
1 September 2025

1 October 2025

Quick facts

Lead sponsor	Leiden University Medical Center
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	280
Start date	1 May 2019
Primary completion	1 September 2025
Estimated completion	1 October 2025
Sites	2 locations across Netherlands

Drugs / interventions tested

Near-infrared fluorescence imaging of perfusion

Conditions studied

Fat Necrosis — all drugs for Fat Necrosis →

Sponsor

Leiden University Medical Center

Who can join

18 and older, female only, with Fat Necrosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Currently during DIEP flap reconstruction, the perfusion of the flap is assessed by the clinical view of the surgeon. Identification of demarcated ischemic zones of the DIEP flap could be optimized by using fluorescence imaging with indocyanine green (ICG) in order to lower the rate of fat necrosis. This study evaluates whether intraoperative perfusion assessment with ICG fluorescence imaging causes a lower rate of fat necrosis compared to conventional intraoperative clinical evaluation of DIEP flaps.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Near-infrared fluorescence angiography with indocyanine green for perfusion assessment of DIEP and msTRAM flaps: A Dutch multicenter randomized controlled trial.
Tange FP, Verduijn PS, Sibinga Mulder BG, van Capelle L, et al · · 2023 · cited 10× · PMID 37091505 · DOI 10.1016/j.conctc.2023.101128
Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.
Tange FP, Peul RC, van den Hoven P, Koning S, et al · · 2025 · cited 2× · PMID 39777554 · DOI 10.1007/s00423-024-03589-1

Verify or expand the search:

Other trials of Near-infrared fluorescence imaging of perfusion

Trials testing the same drug.

NCT06034834 — Near-Infrared Imaging for Perfusion Assessment of Traumatic Soft Tissue and Skeletal Injuries · NA · unknown

Other Leiden University Medical Center trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05507710 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Leiden University Medical Center
Last refreshed: 19 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05507710.

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