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NCT05505396: BRAIN-GLULAC
Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury
trial testing Sampling of blood and cerebrospinal fluid in Acute Brain Injury in 459 participants. Completed in 30 October 2024.
30 April 2024
Quick facts
| Lead sponsor | Rigshospitalet, Denmark |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 459 |
| Start date | 24 October 2022 |
| Primary completion | 30 April 2024 |
| Estimated completion | 30 October 2024 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Sampling of blood and cerebrospinal fluid
Conditions studied
- Acute Brain Injury — all drugs for Acute Brain Injury →
- Hyperglycemia — all drugs for Hyperglycemia →
- Hyperlactatemia — all drugs for Hyperlactatemia →
Sponsor
Rigshospitalet, Denmark
Who can join
18 and older, any sex, with Acute Brain Injury or Hyperglycemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome. Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05505396
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Sampling of blood and cerebrospinal fluid
Trials testing the same drug.
- NCT07380477 — VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site · recruiting
Other recruiting trials for Acute Brain Injury
Currently open trials in the same condition.
- NCT07380477 — VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site · recruiting
- NCT06542107 — Weaning From Mechanical Ventilation in Patients With Acute Brain Injury · recruiting
- NCT06469801 — ECMO ABI Detection With Hyperfine · NA · recruiting
- NCT06426615 — Connectivity and Neural Signatures of Consciousness in Unresponsive States · NA · recruiting
- NCT04080440 — Brain-injured Patients Extubation Readiness Study · NA · recruiting
Other Rigshospitalet, Denmark trials
Trials by the same sponsor.
- NCT07401368 — Clinicians' Trust in AI-Based Fetal Growth Estimates · NA · not yet recruiting
- NCT07442357 — The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial · NA · not yet recruiting
- NCT07528729 — Alcohol as a Modifiable Risk Factor for Atrial Fibrillation · NA · not yet recruiting
- NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
- NCT07467187 — Invasive Home Ventilation in Denmark · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05505396 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
- Last refreshed: 29 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05505396.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing