NCT05501262

Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma

Recruiting now NA Last updated 16 October 2025

What this trial tests

NA trial testing Cryoablation in Morton Neuroma in 32 participants. Currently enrolling.

Timeline

25 July 2022

Primary endpoint
30 December 2026

31 December 2027

Quick facts

Lead sponsor	Oregon Health and Science University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	32
Start date	25 July 2022
Primary completion	30 December 2026
Estimated completion	31 December 2027
Sites	1 location across United States

Drugs / interventions tested

• Cryoablation — full drug profile →
• Nerve block — full drug profile →

Conditions studied

• Morton Neuroma — all drugs for Morton Neuroma →

Sponsor

Oregon Health and Science University

Who can join

Adults 18 to 105, any sex, with Morton Neuroma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Morton's neuroma is a benign thickening involving the plantar interdigital nerve, most common in middle aged women. Morton's neuroma is one of the most frequent diagnoses seen in the investigators podiatry clinic and is difficult to treat. These lesions cause a burning or shooting pain that can radiate to the toes, or an aching pain in the ball of the foot. The pain is exacerbated with activity and certain footwear greatly limits activity in the involved patient population. Morton's neuroma is first treated conservatively with orthotics. Patients may require further interventions such as steroid injections. The literature reports only a 30% long term resolution of pain with the steroid. Surgical resection has a reported 51-85% success rate with 14-21% rate of complication; recurrent pain, numbness/loss of sensation, and subsequent stump neuromas.

Cryoablation is well known to be efficacious for neuropathic pain and has recently been shown in two small studies to be safe and efficacious for treatment of Morton's neuroma. The investigators study will compare outcomes of cryoablation to corticosteroid injection in short- and long-term for treatment of Morton's neuroma that have failed conservative therapy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Post-traumatic radial nerve neuroma: A case report.
   Rhoul A, Boubcher M, Gartit M, Noumairi M, et al · · 2023 · PMID 37601552 · DOI 10.1016/j.tcr.2023.100913