NCT05500248 is a NA clinical trial of Leave In Situ in Colonic Neoplasms, sponsored by University of Roma La Sapienza.

Who is sponsoring NCT05500248?

NCT05500248 is sponsored by University of Roma La Sapienza.

What drugs are being tested in NCT05500248?

Interventions in NCT05500248: Leave In Situ, Standard.

What condition does NCT05500248 study?

NCT05500248 studies Colonic Neoplasms.

Is NCT05500248 still recruiting?

NCT05500248 is currently completed. Last updated 18 April 2025.

Last reviewed 2025-04-18 · How we verify

NCT05500248

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Artificial Intelligence for Leaving in Situ Colorectal Polyps.

Completed NA Last updated 18 April 2025

What this trial tests

NA trial testing Leave In Situ in Colonic Neoplasms in 919 participants. Completed in 30 August 2024.

Timeline

1 October 2022

Primary endpoint
31 December 2023

30 August 2024

Quick facts

Lead sponsor	University of Roma La Sapienza
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	919
Start date	1 October 2022
Primary completion	31 December 2023
Estimated completion	30 August 2024
Sites	1 location across Italy

Drugs / interventions tested

Leave In Situ
Standard

Conditions studied

Colonic Neoplasms — all drugs for Colonic Neoplasms →

Sponsor

University of Roma La Sapienza

Who can join

18 and older, any sex, with Colonic Neoplasms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This two parallel-arms, randomized, multicenter trial is aimed at investigating safety and effectiveness of a Computer-Aided-Diagnosis (CADx)-assisted leave-in-situ strategy (Leave-In-Situ Arm) as opposed to a resect-all strategy (Standard Arm) as implemented by endoscopists in a real-world setting. With this study it will be possible to understand the impact of CADx in patient treatment and management both in terms of clinical outcome and costs.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Safety of artificial intelligence-assisted optical diagnosis for leaving colorectal polyps in situ during colonoscopy (PRACTICE): a non-inferiority, randomised controlled trial.
Antonelli G, Desideri F, Scarozza P, Andrisani G, et al · · 2025 · PMID 40914178 · DOI 10.1016/s2468-1253(25)00140-2

Verify or expand the search:

Other recruiting trials for Colonic Neoplasms

Currently open trials in the same condition.

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NCT06124378 — Neoadjuvant Tislelizumab With Chemotherapy for the Treatment of MSS Colon Cancer · Phase 2 · active not recruiting

Other University of Roma La Sapienza trials

Trials by the same sponsor.

NCT07485023 — Oral Versus Intravenous Iron for Anemia Diagnosed After 34 Weeks of Gestation · NA · not yet recruiting
NCT07305519 — The Combined Effect of Magnesium, Palmitoylethanolamide, High-Molecular-weight Hyaluronic Acid, Vitamin B6, and Vitamin · NA · not yet recruiting
NCT07520968 — ABX Versus CHX in NSPT: a RCT · NA · active not recruiting
NCT07109596 — Integration of Clinical, Biological and Psycho-social Variables for a Gender-sensitive Frailty Prediction · recruiting
NCT07490574 — Trial of Underwater Versus Gas-Insufflation Colorectal Endoscopic Submucosal DisseEtion · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05500248 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Roma La Sapienza
Last refreshed: 18 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05500248.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing