Who is sponsoring NCT05497999?

NCT05497999 is sponsored by Harvard Medical School (HMS and HSDM).

What drugs are being tested in NCT05497999?

Interventions in NCT05497999: Proactive Outreach, No Proactive Outreach.

What condition does NCT05497999 study?

NCT05497999 studies Chronic Obstructive Pulmonary Disease.

Is NCT05497999 still recruiting?

NCT05497999 is currently completed. Last updated 14 March 2023.

Last reviewed 2023-03-14 · How we verify

NCT05497999

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Racial Inequality in Inhaler Fills for COPD - A Trial of Reduced Cost-Sharing

Completed NA Last updated 14 March 2023

What this trial tests

NA trial testing Proactive Outreach in Chronic Obstructive Pulmonary Disease in 19,113 participants. Completed in 31 December 2022.

Timeline

7 January 2020

Primary endpoint
31 December 2022

31 December 2022

Quick facts

Lead sponsor	Harvard Medical School (HMS and HSDM)
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	health services research
Enrollment	19,113
Start date	7 January 2020
Primary completion	31 December 2022
Estimated completion	31 December 2022
Sites	3 locations across United States

Drugs / interventions tested

Proactive Outreach
No Proactive Outreach

Conditions studied

Chronic Obstructive Pulmonary Disease — all drugs for Chronic Obstructive Pulmonary Disease →

Sponsor

Harvard Medical School (HMS and HSDM)

Who can join

Eligibility, any sex, with Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In partnership with a large Medicare Advantage (MA) insurer (Humana, Inc.) and as part of a Center for Medicare and Medicaid Innovation demonstration program of Value-Based Insurance Design (VBID), the investigators propose to study a randomized controlled quality improvement trial in which Humana randomized MA beneficiaries with COPD to receive proactive outreach for a VBID benefit that provided large reductions in cost-sharing for their maintenance inhalers and telephone-based COPD medication management services in 2020 and 2021. The investigators will analyze changes in racial disparities for inhaler fills, clinical outcomes, health care spending, and acute care utilization.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Reduced Cost Sharing and Medication Management Services for COPD: A Randomized Clinical Trial.
Agarwal SD, Metzler E, Chernew M, Thomas E, et al · · 2024 · cited 4× · PMID 39073823 · DOI 10.1001/jamainternmed.2024.3499
Abstracts from the 2024 Annual Meeting of the Society of General Internal Medicine
· 2024

Verify or expand the search:

Other trials of Proactive Outreach

Trials testing the same drug.

NCT04462289 — Electronic Proactive Outreach for Smokers With COPD · NA · completed

Other recruiting trials for Chronic Obstructive Pulmonary Disease

Currently open trials in the same condition.

NCT06749262 — Inclined Versus Standard Exercise for COPD Patients · NA · recruiting
NCT07406659 — Different Inspiratory Muscle Trainings in Patients With COPD · NA · recruiting
NCT07051707 — Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD · NA · recruiting
NCT07418736 — A Phase II Study of CM326 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease · Phase 2 · recruiting
NCT07069829 — Study of Clinical and Patient-reported Outcomes in Adults With Moderate to Severe COPD Treated With Breztri/Trixeo · recruiting

Other Harvard Medical School (HMS and HSDM) trials

Trials by the same sponsor.

NCT07440303 — Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT · NA · recruiting
NCT07203885 — AI-Assisted Acute Myeloid Leukemia Evaluation With the Leukemia End-to-End Analysis Platform (LEAP) Versus Clinician-Onl · NA · completed
NCT07090863 — Additively Versus Subtractively Manufactured Implant Supported Fixed Dental Prostheses · NA · not yet recruiting
NCT07307157 — Head-to-Head Evaluation of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI System Versus Pathologist- · enrolling by invitation
NCT06651502 — Efficacy of a Dental Implant System for Immediate Restoration · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05497999 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Harvard Medical School (HMS and HSDM)
Last refreshed: 14 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05497999.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing