Last reviewed · How we verify
NCT05497219: NIA_RV
Reference Values for Videofluoroscopic Measures of Swallowing
NA trial testing Videofluoroscopic Swallowing Study (VF) in Dysphagia, Oropharyngeal in 580 participants. Enrolling by invitation.
30 November 2026
Quick facts
| Lead sponsor | University Health Network, Toronto |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 580 |
| Start date | 15 November 2022 |
| Primary completion | 30 November 2026 |
| Estimated completion | 31 July 2027 |
| Sites | 5 locations across Canada, United States |
Drugs / interventions tested
- Videofluoroscopic Swallowing Study (VF)
Conditions studied
- Dysphagia, Oropharyngeal — all drugs for Dysphagia, Oropharyngeal →
Sponsor
University Health Network, Toronto
Who can join
18 and older, any sex, with Dysphagia, Oropharyngeal. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international "gold standard" dysphagia diagnostic exam, there is a paucity of available normative physiologic VF reference values in healthy adults across the age span to guide interpretation of these examinations. In this project, the investigators will extend previous work on the quantitative measurement of swallowing physiology from VF examinations to establish reference values for swallowing in healthy adults, and to identify clinical decision point values for differentiating healthy swallowing across the age span from disordered swallowing in several high-risk clinical populations to study dysphagia.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Introducing the Modified Cobb Angle for Measuring Cervical Spine Curvature During Swallowing.
Steele CM, Grady MO, Farpour S, Peladeau-Pigeon M, et al · · 2025 · PMID 41427438 · DOI 10.1002/lio2.70333
Verify or expand the search:
- PubMed search for NCT05497219
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Health Network, Toronto trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05497219 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Health Network, Toronto
- Last refreshed: 8 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05497219.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing