Last reviewed · How we verify
NCT05496881
Exercise Effects in Multiple Sclerosis
NA trial testing Exercise Group 1 in Multiple Sclerosis, Primary Progressive in 69 participants. Status unknown.
31 October 2024
Quick facts
| Lead sponsor | University of Regina |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | supportive care |
| Enrollment | 69 |
| Start date | 15 June 2022 |
| Primary completion | 31 October 2024 |
| Estimated completion | 30 April 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Exercise Group 1
- Exercise Group 2
- Exercise Group 3
Conditions studied
- Multiple Sclerosis, Primary Progressive — all drugs for Multiple Sclerosis, Primary Progressive →
- Multiple Sclerosis, Relapsing-Remitting — all drugs for Multiple Sclerosis, Relapsing-Remitting →
- Multiple Sclerosis, Secondary Progressive — all drugs for Multiple Sclerosis, Secondary Progressive →
- Multiple Sclerosis, Chronic Progressive — all drugs for Multiple Sclerosis, Chronic Progressive →
Sponsor
University of Regina
Who can join
18 and older, any sex, with Multiple Sclerosis, Primary Progressive or Multiple Sclerosis, Relapsing-Remitting. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A growing body of work suggests that regular exercise can support symptom management and improve physical function for people living with multiple sclerosis (MS). Although exercise is known to be beneficial for managing many symptoms related to MS, its effects on the central nervous system, and whether these effects change with different types of exercise, are not well understood. Here, the investigators have designed a clinical trial that compares the effects of distinct exercise protocols on aspects of physical function, physical fitness, and central nervous system function. This research will be the first to compare the effects of different types of exercise on central nervous system changes in people with MS.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications.
Chen Z, Mao Z, Tang W, Shi Y, et al · · 2025 · cited 4× · PMID 41299782 · DOI 10.1186/s40035-025-00517-1 -
Task-oriented exercise effects on walking and corticospinal excitability in multiple sclerosis: protocol for a randomized controlled trial.
Moslemi Z, Toledo-Aldana EA, Baldwin B, Donkers SJ, et al · · 2023 · cited 1× · PMID 38129896 · DOI 10.1186/s13102-023-00790-5 -
Task-oriented exercise effects on walking and corticospinal excitability in multiple sclerosis: protocol for a randomized controlled trial
Moslemi Z, Toledo-Aldana EA, Baldwin B, Donkers SJ, et al · · 2023 · DOI 10.21203/rs.3.rs-3293650/v1
Verify or expand the search:
- PubMed search for NCT05496881
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Multiple Sclerosis, Primary Progressive
Currently open trials in the same condition.
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- NCT05204459 — MS-ResearchBiomarkerS · recruiting
- NCT04544449 — A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary · Phase 3 · active not recruiting
- NCT04035005 — A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis · Phase 3 · active not recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05496881 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Regina
- Last refreshed: 15 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05496881.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing