NCT05496387

Effect of Neuromobılızatıon on Stiffness of Scıatıc Nerve

Completed NA Last updated 15 April 2025

What this trial tests

NA trial testing Sciatic nerve neuromobilization techniques in Neuromobılızatıon in 36 participants. Completed in 15 November 2022.

Timeline

15 October 2022

Primary endpoint
15 October 2022

15 November 2022

Quick facts

Lead sponsor	Istinye University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	36
Start date	15 October 2022
Primary completion	15 October 2022
Estimated completion	15 November 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Sciatic nerve neuromobilization techniques

Conditions studied

• Neuromobılızatıon — all drugs for Neuromobılızatıon →
• Stiffness — all drugs for Stiffness →
• Scıatıc Nerve — all drugs for Scıatıc Nerve →
• Nonspecific Low Back Pain — all drugs for Nonspecific Low Back Pain →

Sponsor

Istinye University

Who can join

Adults 18 to 64, any sex, with Neuromobılızatıon or Stiffness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Low back pain (LBP) is a common symptom that can be a health problem in worldwide. Studies have shown that 70% to 80% of all people are affected at least once in their lives. Although it is common, the cause of the pain has often not been determined and is referred to as non-specific LBP. The lumbar range of motion decreases, trunk flexion is limited, postural control and muscular stiffness are affected in individuals with LBP. Recent studies have shown that people with LBP have altered nerve properties in the sciatic nerve. It was observed that the cross-sectional area of the sciatic nerve decreased and its stiffness increased.

Peripheral nerve tissues are faced with great tension and compressive forces that occur in daily life activities and sports activities. To maintain the normal function of the nervous system, it must have the ability to resistance to tension, easy to slide in the environment it is in and withstand compressive forces. In case of not being able to resist the pressure exerted by surrounding tissues such as bone, tendon, muscle, fascia, there may be distortions in the shapes of neural structures.

Neuromobilization, one of the manual therapy techniques, is used in impingement syndromes of peripheral nerves and neuropathies. Neuromobilization aims to regain the normal mechanical properties of the nerve by using limb movements, motion and position of the joint. There are two methods of neuromobilization techniques; sliding and tension. Sliding involves combinations of movements that lengthen the nerve bed in one joint and reduce the length of the nerve bed in the next joint, while tension is done by stretching both ends of the nerve bed. Neuromobilization structures the balance between the relative movements of the neural tissues and the surrounding mechanical interface, allows the reduction of internal pressure in the neural tissue, and thus optimum physiological functions are regulated. The mechanism of action of neuromobilization is thought to be to increase intraneural circulation, improve axoplasmic flow and connective tissue viscoelasticity, and reduce hypersensitive areas.

Neuromobilization techniques are extensively used in clinical settings during the therapy of patients with sciatica, with favorable effects on pain and impairment. However, the mechanical implications of neuromobilization in human nerves are poorly understood. Two investigations that used SWE to measure sciatic nerve stiffness in healthy adults following prolonged slump positions came up with conflicting conclusions. It has been determined that there are different opinions on the effects of slump neuromobilizations in sciatic nerves. Considering that slump neuromobilization techniques are frequently used for therapeutic, it should be appropriate to determine their effects on the sciatic nerve.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.