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NCT05494671
Studying Corneal Epithelial Stability Following Limbal Stem Cell Transplantation in Cases of Limbal Stem Cell Deficiency
NA trial testing conjunctival limbal autologous transplant in Stem Cell Transplantation in 12 participants. Status unknown.
10 January 2023
Quick facts
| Lead sponsor | Cairo University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 12 |
| Start date | 1 January 2022 |
| Primary completion | 10 January 2023 |
| Estimated completion | 1 November 2023 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- conjunctival limbal autologous transplant
Conditions studied
- Stem Cell Transplantation — all drugs for Stem Cell Transplantation →
Sponsor
Cairo University
Who can join
Adults 15 to 70, any sex, with Stem Cell Transplantation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Integrity of the corneal epithelium is the function of intact limbal stem cells. The reduction in the population of LSCs and their dysfunction result in abnormal corneal epithelialization and invasion of the corneal surface by the conjunctival epithelium with or without corneal neovascularization that is, limbal stem cell deficiency (LSCD). Different techniques have been developed to treat cases of limbal stem cell deficiency due to traumatic or congenital cases. Recent innovations developed to predict the early stages of stem cell deficiency. One of these methods is measurement of the central epithelial thickness as it was found that limbal stem cell deficiency causes reduction of the central epithelial thickness. The aim of this study is to study changes in the corneal epithelial thickness at different quadrants of the cornea to observe the exact time of epithelial stability following stem cell transplantation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges.
Niu Y, Ji J, Yao K, Fu Q. · · 2024 · cited 25× · PMID 38586868 · DOI 10.1016/j.aopr.2024.02.001
Verify or expand the search:
- PubMed search for NCT05494671
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Cairo University trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05494671 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cairo University
- Last refreshed: 30 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05494671.
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