NCT05492487 is a Phase 2 clinical trial of Mirena in Endometrial Hyperplasia, sponsored by KK Women's and Children's Hospital.

Who is sponsoring NCT05492487?

NCT05492487 is sponsored by KK Women's and Children's Hospital.

What drugs are being tested in NCT05492487?

Interventions in NCT05492487: Mirena, Megace.

What condition does NCT05492487 study?

NCT05492487 studies Endometrial Hyperplasia, Fertility Issues, Disease Regression, Treatment Side Effects.

Is NCT05492487 still recruiting?

NCT05492487 is currently status unknown. Last updated 8 August 2022.

Last reviewed 2022-08-08 · How we verify

NCT05492487

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore

Status unknown Phase 2 Last updated 8 August 2022

What this trial tests

Phase 2 trial testing Mirena in Endometrial Hyperplasia in 60 participants. Status unknown.

Timeline

3 January 2020

Primary endpoint
31 March 2023

31 March 2023

Quick facts

Lead sponsor	KK Women's and Children's Hospital
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	60
Start date	3 January 2020
Primary completion	31 March 2023
Estimated completion	31 March 2023
Sites	3 locations across Singapore

Drugs / interventions tested

Mirena
Megace (MEGESTROL ACETATE) — full drug profile →

Conditions studied

Endometrial Hyperplasia — all drugs for Endometrial Hyperplasia →
Fertility Issues — all drugs for Fertility Issues →
Disease Regression — all drugs for Disease Regression →
Treatment Side Effects — all drugs for Treatment Side Effects →

Sponsor

KK Women's and Children's Hospital

Who can join

Adults 21 to 40, female only, with Endometrial Hyperplasia or Fertility Issues. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators' objective is to determine the regression rate, side effects and acceptability of Mirena compared to megace in the treatment of atypical endometrial hyperplasia among women desiring fertility.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A multi-centre randomised controlled trial comparing megestrol acetate to levonorgestrel-intrauterine system in fertility sparing treatment of atypical endometrial hyperplasia.
Goh CSY, Loh MJM, Lim WW, Ang JX, et al · · 2024 · cited 3× · PMID 39215793 · DOI 10.1007/s10815-024-03172-z

Verify or expand the search:

Other trials of Mirena

Trials testing the same drug.

NCT05742503 — Progesterone Containing Contraceptive Methods on Endogenous Progesterone Level · completed
NCT03499379 — Stress Hormones and IUDs · completed
NCT02490774 — To Investigate the Pharmacological Effects, Drug Blood Levels and Safety of an Intrauterine System Releasing the Study D · Phase 2 · terminated

Other recruiting trials for Endometrial Hyperplasia

Currently open trials in the same condition.

NCT06904274 — Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 Months · Phase 3 · recruiting
NCT07077876 — Surgical and Obstetric Outcomes in Endometrial Adenocarcinoma and Atypical Endometrial Hyperplasia With Conservative Tre · recruiting
NCT05903131 — Uterine Preservation Via Lifestyle Transformation · Phase 2 · recruiting
NCT06501846 — Pipelle® Under Ultrasound Guidance (PUG) to Investigate Post-menopausal Bleeding. · NA · recruiting
NCT06417736 — Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women · NA · recruiting

Other KK Women's and Children's Hospital trials

Trials by the same sponsor.

NCT07534670 — Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY · NA · not yet recruiting
NCT07466797 — The eHealth Integrated Maternal Physical Activity Programme in Prenatal Care Trial (E-IMPACT) · NA · recruiting
NCT06457750 — Anthropometric Outcomes of a Mobile Health Intervention for Eating Behaviour and Lifestyle in Infancy · NA · not yet recruiting
NCT06481644 — Asia Pediatric Intensive Care Epidemiology and Outcomes Study · recruiting
NCT06489834 — Group Drumming for Improving the Health of Community-Dwelling Elderly · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05492487 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by KK Women's and Children's Hospital
Last refreshed: 8 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05492487.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing