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NCT05492136: LIVERaTION
Unravelling the Impact of Radiofrecuency in Liver Surgery: the Key to Decrease Local Recurrence?
NA trial testing Additional margin coagulation in Liver Cancer in 720 participants. Currently enrolling.
31 May 2028
Quick facts
| Lead sponsor | Hospital del Mar |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 720 |
| Start date | 1 November 2023 |
| Primary completion | 31 May 2028 |
| Estimated completion | 30 June 2028 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Additional margin coagulation
Conditions studied
- Liver Cancer — all drugs for Liver Cancer →
- Cancer, Treatment-Related — all drugs for Cancer, Treatment-Related →
Sponsor
Hospital del Mar
Who can join
18 and older, any sex, with Liver Cancer or Cancer, Treatment-Related. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Radiofrequency devices have been increasingly employed in liver surgery in order to achieve proper hemostasis and this use has become more evident with the implementation of minimal invasive surgery. Due to its well-known efficacy for tumor ablation (i.e. hepatocarcinoma) it use has been extended in some cases to ablate the liver surface after resection in questionable resection. Till date, despite the majority of surgeons apply an additional coagulation in doubtful margins, there is not an evidence that this maneuver really decreases the local recurrence or increases the overall survival. On the contrary, some studies have suggested that non-anatomical resections in order to spare liver parenchyma could lead to major zones of liver ischemia in the remnant liver and thus favoring recurrence. However, major liver ischemia (defined as grade 2 o more) is unlikely to be provoked by 1 cm-depth additional coagulation of the margin. The investigators previously published in a retrospective study the concept of additional margin coagulation within liver resections and narrow margins and demonstrated that the study group had significantly less local recurrence compared to the controls. Therefore, in the present study the aim is to continue this evaluation through a multicenter randomized clinical trial.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
LIVERATION trial: a multicentre European randomised study on radiofrequency margin coagulation and its impact on oncological outcomes after liver surgery - study protocol.
Luque Villalobos E, Ielpo B, Aldrighetti L, Anselmo A, et al · · 2025 · PMID 41290310 · DOI 10.1136/bmjopen-2025-100518
Verify or expand the search:
- PubMed search for NCT05492136
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05492136 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital del Mar
- Last refreshed: 3 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05492136.
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